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Impairment of Memory Function by Antihypertensive Medication
Sanford Solomon, MD;
Edward Hotchkiss, MD;
Stephen M. Saravay, MD;
Christopher Bayer, PhD;
Pat Ramsey, PhD;
Richard S. Blum, MD
Arch Gen Psychiatry. 1983;40(10):1109-1112.
Abstract
• This study describes a specific memory impairment in subjects taking either of two kinds of centrally active antihypertensive agents. Verbal memory impairment was present in hypertensive and normotensive patients taking methyldopa or propranolol hydrochloride, while hypertensive patients receiving only a diuretic did not show this deficit. Visual memory impairment was not seen in any of the groups tested. The majority of the subjects were unaware of their memory deficit, even when test results clearly revealed impairment. An earlier pilot study of 12 hypertensive patients receiving methyldopa or propranolol used a broad range of cognitive tests and also demonstrated impairment in verbal memory only, while other cognitive measures remained relatively unaffected.
Author Affiliations
From the Long Island Jewish-Hillside Medical Center, New Hyde Park, NY.
Footnotes
Accepted for publication Oct 11, 1982.
Read in part before the American Psychosomatic Society Annual Meeting, New York, March 28, 1980.
Reprint requests to Psychiatric Liaison & Consultation Service, Long Island Jewish-Hillside Medical Center, New Hyde Park, NY 11042 (Dr Solomon).
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