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Arthur K. Shapiro, MD; Elaine Shapiro, PhD; Gail J. Eisenkraft, MA

Arch Gen Psychiatry. 1983;40(11):1235-1240.

Abstract
• In an open clinical trial of clonidine hydrochloride and neuroleptics in patients with Gilles de la Tourette's syndrome, neuroleptics resulted in greater improvement across the range of symptoms in a larger proportion of patients than did clonidine. A small subgroup of patients may have benefited from treatment with clonidine. Carefully controlled, randomized, and double-blind studies are necessary to resolve the divergent views about the effectiveness of clonidine in the treatment of Gilles de la Tourette's syndrome.

Author Affiliations
From the Department of Psychiatry (Drs A. Shapiro and E. Shapiro) and the Tourette and Tic Laboratory and Clinic (Drs A. Shapiro and E. Shapiro and Ms Eisenkraft), Mount Sinai School of Medicine, New York.

Footnotes
Accepted for publication April 1, 1983.

Reprint requests to Tourette and Tic Laboratory and Clinic, Mt Sinai School of Medicine, Annenberg Building, Room 22-72, 1 Gustave L. Levy Pl, New York, NY 10029 (Dr A. Shapiro).

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