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Reliability of Norepinephrine and Major Monoamine Metabolite Measurements in CSF of Schizophrenic Patients
Markku Linnoila, MD, PhD;
Philip T. Ninan, MD;
Mika Scheinin, MD;
Robert N. Waters, MD;
Wen-Ho Chang, MD;
John Bartko, PhD;
Daniel P. van Kammen, MD, PhD
Arch Gen Psychiatry. 1983;40(12):1290-1294.
Abstract
• Concentrations of norepinephrine, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and 5-hydroxyindoleacetic acid (5-HIAA) were quantified in the CSF of 28 drug-free schizophrenic patients. Fifteen patients provided more than one drug-free sample on separate occasions. Considerable intraindividual variability over time was found in the concentrations of norepinephrine and these major monoamine metabolites in the repeated samples. This was not explained by assay errors or changes in the patient's global psychosis ratings. The variability in the present sample for CSF 5-HIAA concentrations was almost twice as wide as has been reported for patients with affective disorder. Variables that contribute much of the variability of norepinephrine and major monoamine metabolite concentrations in drug-free CSF samples from schizophrenic patients remain unknown and cannot be controlled.
Author Affiliations
From the Branches of Clinical Psychobiology (Drs Linnoila, Scheinin, and Chang), Biological Psychiatry (Drs Ninan, Waters, and van Kammen), and Theoretical Statistics and Mathematics (Dr Bartko), National Institute of Mental Health, Bethesda, Md.
Footnotes
Accepted for publication Feb 14, 1983.
Reprint requests to National Institute of Mental Health, Room 4S-239, Bldg 10, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Linnoila).
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