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Studies During Recovery From the Depressive Episode in a Drug-Free State

Joaquim Puig-Antich, MD; Raymond Goetz, MA; Cleo Hanlon, MS; Mary Ann Tabrizi, RN; Mark Davies, MPH; Elliot D. Weitzman, MD

Arch Gen Psychiatry. 1983;40(2):187-192.

Abstract
• The sleep of 28 fully recovered, drug-free, prepubertal patients with major depressive disorder was recorded for three consecutive nights in the laboratory. Recovered depressives had significantly shorter first rapid eye movement period (REMP) latencies and a higher number of REMPs compared with themselves when depressed and with nondepressed neurotic and normal children. In addition, most sleep continuity measures improved considerably on recovery. We suggest that a short first REMP latency may be a marker of past episode or of trait in prepubertal major depressives.

Author Affiliations
From the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York (Dr Puig-Antich, Mr Goetz, Mss Hanlon and Tabrizi, and Mr Davies); and the Laboratory of Human Chronophysiology, Department of Neurology, Albert Einstein College of Medicine, and Montefiore Hospital and Medical Center, Bronx, NY (Dr Weitzman).

Footnotes
Accepted for publication July 21, 1982.

Reprints not available.

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