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Tests Using the Xenon Xe 133 Inhalation Method

Rona Notestine Ariel, MS; Charles J. Golden, PhD; Richard A. Berg, PhD; Merton A. Quaife, MD; J. William Dirksen, PhD; Thomas Forsell, PharmD; James Wilson, PharmD; Benjamin Graber, MD

Arch Gen Psychiatry. 1983;40(3):258-263.

Abstract
• Measurements of intrahemispheric and bilateral regional cerebral blood flow (CBF) for gray and white matter were compared in 29 schizophrenic patients and 22 normal controls, using the xenon Xe 133 inhalation method. Results showed significantly lower CBF values for all brain regions in the schizophrenic group, and post hoc comparisons showed relatively greater reduced gray-matter CBF values in the anterior areas of the brain. There was also a left-hemisphere frontal loss similar to that reported previously, although it was in the context of a generalized loss in anterior functioning. Interhemispheric comparison within both groups showed no differences between homologous regions for gray matter, and greater white-matter CBF values in the right hemisphere than in the left hemisphere. The findings support a hypothesis of a bilateral anterior deficit in schizophrenia.

Author Affiliations
From the University of Nebraska Medical Center, Omaha. Dr Dirksen is now with BSD Medical Corp, University of Utah Research Park, Salt Lake City.

Footnotes
Accepted for publication Sept 15, 1982.

Reprint requests to University of Nebraska Medical Center, 602 S 45th St, Omaha, NE 68106 (Dr Golden).

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