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Kinetics and Clinical Effects of Diazepam and Oxazepam

Carl Salzman, MD; Richard I. Shader, MD; David J. Greenblatt, MD; Jerold S. Harmatz

Arch Gen Psychiatry. 1983;40(3):293-297.

Abstract
• Oxazepam and diazepam were compared in healthy elderly volunteers. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more profound. Diazepam accumulation was extensive, washout was slow and active compounds were present two weeks after the last dose. Oxazepam accumulation was significantly less and elimination significantly faster than diazepam. There was no difference between oxazepam and diazepam in sedation or fatigue during the drug treatment, but sedative effects persisted for two weeks after diazepam therapy was discontinued. Sedation rapidly returned to baseline in the oxazepam group. Thus, the differing pharmacokinetic profiles of diazepam and oxazepam have clinical consequences during multiple dosage in the elderly.

Author Affiliations
From the Psychopharmacology Research Laboratory, Harvard Medical School and Massachusetts Mental Health Center (Dr Salzman), and the Department of Psychiatry (Dr Shader and Mr Harmatz) and the Division of Clinical Pharmacology (Dr Greenblatt), Tufts University School of Medicine and the New England Medical Center Hospital, Boston.

Footnotes
Accepted for publication March 12, 1982.

Reprint requests to Clinical Psychopharmacology Service, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115 (Dr Salzman).

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