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CSF Prostaglandin Levels in Depressed and Schizophrenic Patients
Markku Linnoila, MD, PhD;
A. Richard Whorton, PhD;
David R. Rubinow, MD;
Rex W. Cowdry, MD;
Philip T. Ninan, MD;
Robert N. Waters, MD
Arch Gen Psychiatry. 1983;40(4):405-406.
Abstract
• High prostaglandin E2 concentrations were found in the CSF of women with unipolar depression and character disorder. This finding seemed to be relatively specific; it was not observed in bipolar depressed and psychotic schizophrenic patients.
Author Affiliations
From the Clinical Psychobiology (Drs Linnoila and Cowdry) and Biological Psychiatry (Drs Rubinow, Ninan, and Waters) Branches, National Institute of Mental Health, Bethesda, Md, and the Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC (Dr Whorton).
Footnotes
Accepted for publication July 21, 1982.
Reprint requests to National Institute of Mental Health, Bldg 10, Room 4S239, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Linnoila).
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