 |
|
CSF Somatostatin in Affective Illness
David R. Rubinow, MD;
Philip W. Gold, MD;
Robert M. Post, MD;
James C. Ballenger, MD;
Rex Cowdry, MD;
Judy Bollinger;
Seymour Reichlin, MD, PhD
Arch Gen Psychiatry. 1983;40(4):409-412.
Abstract
• Somatostatin is a hypothalamic tetradecapeptide with many actions. We investigated a potential role for somatostatinergic neuron dysfunction in affective disorder by measuring somatostatin in the CSF of 47 patients with affective illness and of 39 normal volunteers. Medication-free depressed patients showed significantly lower levels of CSF somatostatin than normal volunteers (P<.001) or patients during the improved state (P<.01). A significant inverse correlation was observed between somatostatin and the duration of sleep on the night of the lumbar puncture. We also observed significant correlations between somatostatin and 5-hydroxyindoleacetic acid and norepinephrine in the CSF. Also noted were the significance of depression-related decreases in CSF somatostatin in relation to information about central somatostatin secretion, reported abnormalities of somatostatin activity, and potential interactions between alterations in somatostatin activity and the pathophysiology of depression.
Author Affiliations
From the Biological Psychiatry Branch (Drs Rubinow, Gold, and Post) and the Neuroscience Branch (Dr Cowdry), National Institute of Mental Health, Bethesda, Md; the Department of Behavioral Medicine and Psychiatry, University of Virginia Medical Center, Charlottesville (Dr Ballenger); and Tufts New England Medical Center, Boston (Ms Bollinger and Dr Reichlin).
Footnotes
Accepted for publication Sept 29, 1982.
Reprint requests to Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, Bldg 10, Rm 35-239, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Rubinow).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Bipolar Disorder and Epilepsy: A Bidirectional Relation? Neurobiological Underpinnings, Current Hypotheses, and Future Research Directions
Mazza et al.
Neuroscientist 2007;13:392-404.
ABSTRACT
Serotonin Function and the Mechanism of Antidepressant Action: Reversal of Antidepressant-Induced Remission by Rapid Depletion of Plasma Tryptophan
Delgado et al.
Arch Gen Psychiatry 1990;47:411-418.
ABSTRACT
Dysphoric Mania: Clinical and Biological Correlates
Post et al.
Arch Gen Psychiatry 1989;46:353-358.
ABSTRACT
Antisomatostatin IgG in Major Depressive Disorder: A Preliminary Study With Implications for an Autoimmune Mechanism of Depression
Roy et al.
Arch Gen Psychiatry 1988;45:924-928.
ABSTRACT
Somatostatin Immunoreactivity in Postmortem Brain From Depressed Suicides
Charlton et al.
Arch Gen Psychiatry 1988;45:597-597.
ABSTRACT
Somatostatin Immunoreactivity in Postmortem Brain From Depressed Suicides-Reply
Bissette and Nemeroff
Arch Gen Psychiatry 1988;45:597-598.
ABSTRACT
Alterations in Cerebrospinal Fluid Concentrations of Somatostatinlike Immunoreactivity in Neuropsychiatric Disorders
Bissette et al.
Arch Gen Psychiatry 1986;43:1148-1151.
ABSTRACT
CSF Somatostatin and Abnormal Response to Dexamethasone Administration in Schizophrenic and Depressed Patients
Doran et al.
Arch Gen Psychiatry 1986;43:365-369.
ABSTRACT
Cerebrospinal Fluid Vasopressin, Oxytocin, sopressin, Oxytoc in Alzheimer's Diseas{beta}-Endorphin
Raskind et al.
Arch Gen Psychiatry 1986;43:382-388.
ABSTRACT
Neuroendocrine Changes in Depression
Joyce
Aust N Z J Psychiatry 1985;19:120-127.
ABSTRACT
Somatostatin Receptors
Maurer and Reubi
JAMA 1985;253:2741-2741.
Lymphocyte Function in Major Depressive Disorder
Schleifer et al.
Arch Gen Psychiatry 1984;41:484-486.
ABSTRACT
|
