This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David B. Jarrett, MD; Patricia A. Coble; David J. Kupfer, MD

Arch Gen Psychiatry. 1983;40(5):506-511.

Abstract
• Depressed patients commonly have disturbances in their sleep and cortisol secretory patterns. When the sleep-related changes in plasma cortisol concentration were measured in 14 patients with a primary major depressive illness, they differed significantly from the changes measured in 14 age- and sexmatched healthy control subjects. The nadir of the nocturnal plasma cortisol concentration was significantly greater in the group of depressed patients, and the nocturnal increase in the plasma cortisol concentration occurred significantly closer to sleep onset in these patients. The circadian activity within the hypothalamic-pituitary-adrenal axis of these depressed patients showed a subtle but significantly disturbed temporal relationship to sleep onset. This reduced time between sleep onset and the nocturnal increase in cortisol secretion suggests a possible biologic correlate of a depressive illness that might be useful as an illness marker in depressed patients.

Author Affiliations
From the Department of Psychiatry, University of Pittsburgh School of Medicine and the Western Psychiatric Institute and Clinic, Pittsburgh.

Footnotes
Accepted for publication Dec 7, 1982.

Reprint requests to Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213 (Dr Jarrett).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The 24-Hour Profiles of Cortisol, Prolactin, and Growth Hormone Secretion in Mania
Linkowski et al.
Arch Gen Psychiatry 1994;51:616-624.
ABSTRACT  

Circadian and Sleep-Related Endocrine Rhythms in Schizophrenia
Van Cauter et al.
Arch Gen Psychiatry 1991;48:348-356.
ABSTRACT  

Recurrent Depression Is Associated With a Persistent Reduction in Sleep-Related Growth Hormone Secretion
Jarrett et al.
Arch Gen Psychiatry 1990;47:113-118.
ABSTRACT  

Cortisol Secretion in Prepubertal Children With Major Depressive Disorder: Episode and Recovery
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:801-809.
ABSTRACT  

The 24-Hour Profile of Plasma Prolactin in Men With Major Endogenous Depressive Illness
Linkowski et al.
Arch Gen Psychiatry 1989;46:813-819.
ABSTRACT  

Neuroendocrine Aspects of Primary Endogenous Depression: I. Cortisol Secretory Dynamics in Patients and Matched Controls
Rubin et al.
Arch Gen Psychiatry 1987;44:328-336.
ABSTRACT  

Enhanced Adrenal Sensitivity to Exogenous Cosyntropin (ACTH {alpha}1-24) Stimulation in Major Depression: Relationship to Dexamethasone Suppression Test Results
Jaeckle et al.
Arch Gen Psychiatry 1987;44:233-240.
ABSTRACT  

Pituitary-Adrenal Axis Rhythm Disturbances in Psychiatric Depression
Pfohl et al.
Arch Gen Psychiatry 1985;42:897-903.
ABSTRACT  

Cortisol Secretion in Endogenous Depression: II. Time-Related Functions
Halbreich et al.
Arch Gen Psychiatry 1985;42:909-914.
ABSTRACT