This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John M. Morihisa, MD; Frank H. Duffy, MD; Richard J. Wyatt, MD

Arch Gen Psychiatry. 1983;40(7):719-728.

Abstract
• A new topographic approach, brain electrical activity mapping, summarizes EEG and evoked potential data as color maps. Eleven drug-free and 14 medicated schizophrenic patients and 11 normal controls were studied with this technique. Compared with controls, both schizophrenic groups had more slow activity (delta, 0 to 3.5 Hz), greatest in frontal regions, and more fast activity (beta, 20 to 31.5 Hz) in postcentral regions. Both schizophrenic groups were different from controls late in the visual evoked potential and in the middle of the auditory evoked potential. Overall, using multivariate discriminant analysis, a very significant group separation effect was found, and retrospective classification was 95% successful in discriminating both schizophrenic groups from controls. To estimate the ability of our features to assign subjects prospectively to control or patient groups, we employed "jackknifing," which resulted in overall classification success rates of 84.0% for medicated schizophrenic patients v controls and 81.8% for drug-free schizophrenic patients v controls.

Author Affiliations
From the Clinical Neurophysiology Unit (Dr Morihisa) and the Adult Psychiatry Branch, Intramural Research Program (Dr Wyatt), National Institute of Mental Health, St Elizabeths Hospital, Washington, DC; and the Departments of Neurology, Harvard Medical School and Childrens Hospital Medical Center, Boston (Dr Duffy).

Footnotes
Accepted for publication Jan 24, 1983.

Reprint requests to Clinical Neurophysiology Unit, National Institute of Mental Health, William A. White Bldg, Room 536, St Elizabeths Hospital, Washington, DC 20032 (Dr Morihisa).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

EEG Power Spectra Differentiate Positive and Negative Subgroups in Neuroleptic-Naive Schizophrenia Patients
John et al.
J. Neuropsychiatry Clin. Neurosi. 2009;21:160-172.
ABSTRACT | FULL TEXT  

Conventional and Quantitative Electroencephalography in Psychiatry
Hughes and John
J. Neuropsychiatry Clin. Neurosi. 1999;11:190-208.
ABSTRACT | FULL TEXT  

Late Auditory Magnetic Sources May Differ in the Left Hemisphere of Schizophrenic Patients: A Preliminary Report
Reite et al.
Arch Gen Psychiatry 1989;46:565-572.
ABSTRACT  

Computed Electroencephalographic Activity Mapping in Schizophrenia: The Resting State Reconsidered
Karson et al.
Arch Gen Psychiatry 1987;44:514-517.
ABSTRACT  

Structural Abnormalities in the Frontal System in Schizophrenia: A Magnetic Resonance Imaging Study
Andreasen et al.
Arch Gen Psychiatry 1986;43:136-144.
ABSTRACT  

Gilles de la Tourette's Syndrome: A Review of Clinical and Research Studies and Consideration of Future Directions for Investigation
Caine
Arch Neurol 1985;42:393-397.
ABSTRACT  

Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders
Buchsbaum et al.
Arch Gen Psychiatry 1984;41:1159-1166.
ABSTRACT