This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Markku Linnoila, MD, PhD; Farouk Karoum, PhD; William Z. Potter, MD, PhD

Arch Gen Psychiatry. 1983;40(9):1015-1017.

Abstract
• Effects of five antidepressant treatments—clorgyline, desipramine hydrochloride, electroconvulsive treatment, lithium carbonate, and zimelidine hydrochloride—on urinary outputs of dopamine, dihydroxyphenylacetic acid, and homovanillic acid (HVA) were investigated in unipolar and bipolar depressed patients. Clorgyline and lithium carbonate, which stabilized mood in bipolar patients, reduced the urinary output of HVA and whole-body dopamine turnover. Electroconvulsive treatment and zimelidine were without major effects, whereas desipramine had variable effects on these indexes of dopamine metabolism. Three patients, two receiving desipramine and one receiving clorgyline, who had increased HVA output during the drug treatments, became severely agitated and delusional.

Author Affiliations
From the Clinical Psychology (Drs Linnoila and Potter) and Adult Psychiatry (Dr Karoum) Branches, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Jan 5, 1983.

Reprint requests to National Institute of Mental Health, Room 4S-239, Bldg 10, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Linnoila).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lithium Treatment and Serotoninergic Function: Neuroendocrine and Behavioral Responses to Intravenous Tryptophan in Affective Disorder
Price et al.
Arch Gen Psychiatry 1989;46:13-19.
ABSTRACT  

High Correlations of Norepinephrine, Dopamine, and Epinephrine and Their Major Metabolite Excretion Rates
Linnoila et al.
Arch Gen Psychiatry 1988;45:701-704.
ABSTRACT  

Preliminary Evidence of Reduced Combined Output of Dopamine and Its Metabolites in Chronic Schizophrenia
Karoum et al.
Arch Gen Psychiatry 1987;44:604-607.
ABSTRACT  

Dopaminergic Effects of Carbamazepine: Relationship to Clinical Response in Affective Illness
Post et al.
Arch Gen Psychiatry 1986;43:392-396.
ABSTRACT  

Selective Antidepressants and Cerebrospinal Fluid: Lack of Specificity on Norepinephrine and Serotonin Metabolites
Potter et al.
Arch Gen Psychiatry 1985;42:1171-1177.
ABSTRACT  

Five Antidepressant Treatments in Depressed Patients: Effects on Urinary Serotonin and 5-Hydroxyindoleacetic Acid Output
Linnoila et al.
Arch Gen Psychiatry 1984;41:688-692.
ABSTRACT