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Markku Linnoila, MD, PhD; Ewen MacDonald, PhD; Matti Reinila, MSc; Andre Leroy, PhD; David R. Rubinow, MD; Frederick K. Goodwin, MD

Arch Gen Psychiatry. 1983;40(9):1021-1026.

Abstract
• Red blood cell Na⁺, K⁺-, Mg²⁺-, and Ca²⁺-adenosine triphosphatase (ATPase) activities were studied longitudinally in eight patients with affective disorders and 12 healthy volunteers. The patients had a higher mean Ca²-ATPase activity than the volunteers, and the fluctuations in all three ATPase activities were greater in the patients than in the volunteers. Even though the mean Ca²⁺-ATPase activity was higher during manias and euthymic periods than during depressions, mood and ATPase activities did not correlate with each other in all patients. Lithium carbonate treatment did not alter the ATPase activities, and the quantity of vanadium present in the membranes could not account for the variations in the enzyme activities observed. We suggest that either the RBCs of manicdepressive patients are very sensitive to fluctuations of a lipophilic ATPase activity—regulating factor present in plasma or the patients have at times high levels of such a factor. In some patients, the level of this hypothesized regulator may fluctuate in synchrony with mood changes.

Author Affiliations
From the National Institute of Mental Health (Drs Linnoila, Rubinow, and Goodwin), the National Institute of Neurology and Communicative Disorders and Stroke (Dr MacDonald and Ms Reinila), and the Division of Research Services (Dr Leroy), Bethesda, Md.

Footnotes
Accepted for publication Nov 15, 1982.

Reprint requests to National Institute of Mental Health, Bldg 10, Room 4S239, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Linnoila).

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