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A Comparison of Symptomatology and Course of Illness

Kenneth S. Kendler, MD; Peter Hays, MB, FRCP(C)

Arch Gen Psychiatry. 1983;40(9):951-955.

Abstract
• Schizophrenics meeting DSM-III criteria were divided, based on family history of affective disorder in first-degree relatives, into three groups: N-schizophrenics, no relative with affective disorder; U-schizophrenics, a relative with unipolar affective disorder; and B-schizophrenics, a relative with dipolar affective disorder. Although N- and U-schizophrenics displayed similar symptoms during the prodromal, actively psychotic, and remitted stages of their illness, U-schizophrenics were significantly more likely to have a depressive syndrome develop during the follow-up period. Compared with N-schizophrenics, B-schizophrenics were more depressed during the prodrome, were more elated and catatonic when actively psychotic, had fewer residual symptoms when remitted, and were much more likely to have a manic syndrome develop during the follow-up period. Even when DSM-III criteria are met, hesitation is indicated in diagnosing schizophrenia in patients with a first-degree relative with bipolar illness.

Author Affiliations
From the Department of Psychiatry and Schizophrenia Biologic Research Center, Bronx Veterans Administration Medical Center, Mt Sinai School of Medicine, Bronx, NY (Dr Kendler), and the Department of Psychiatry, University of Alberta, Edmonton (Dr Hays).

Footnotes
Accepted for publication Oct 25, 1982.

Reprint requests to Department of Psychiatry, Bronx VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Kendler).

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