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The Association Between Early Parental Loss and Diagnosis in the Iowa 500
Bruce Pfohl, MS, MD;
Dalene Stangl, MA;
Ming T. Tsuang, MD, PhD, DSc
Arch Gen Psychiatry. 1983;40(9):965-967.
Abstract
While a number of studies have found an association between the experience of death of a parent during childhood and the later development of depression as an adult, few of these studies have controlled for possible confounders such as social class, sibship size, parental age at birth, and the patient's age at admission. The results of several studies that do control for such confounders have been negative. The authors investigated the frequency of parental loss and parental death among 129 depressives, 155 schizophrenics, and 63 manics from the Iowa 500 data base. Using a logistic regression to control for confounders, depressives are found to experience early maternal death 3.4 times more frequently than the schizophrenics and 2.1 times more frequently than the bipolars. The failure to confirm other hypotheses and possible implications are discussed.
Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Footnotes
Accepted for publication Aug 19, 1982.
Reprint requests to Department of Psychiatry, University of Iowa, 500 Newton Rd, Iowa City, IA 52242 (Dr Pfohl).
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