This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Plasma Levels and Prolactin Response as Predictors of Clinical Improvement in Schizophrenia: Chemical v Radioreceptor Plasma Level Assays

Robert C. Smith, MD, PhD; Richard Baumgartner, PhD; Chandra H. Misra, PhD; Mary Mauldin, MA; Alla Shvartsburd, MS; Beng T. Ho, PhD; Charles DeJohn, PhD, MD

Arch Gen Psychiatry. 1984;41(11):1044-1049.

Abstract
• The relationship between clinical response of schizophrenic patients to haloperidol and (1) blood levels of the medication, determined by both gas-liquid chromatography (GLC) and radioreceptor (RR) assays, or (2) prolactin response to the medication, was examined in an inpatient study using several fixed doses of haloperidol. Regression analysis disclosed a substantial curvilinear relationship between steadystate GLC-determined plasma haloperidol levels and decrease in Brief Psychiatric Rating Scale (BPRS) Psychosis factor scores; however, no substantial relationship was found between clinical response and RR plasma haloperidol levels or serum prolactin response to haloperidol. Our results suggest that steady-state plasma levels of haloperidol determined by the GLC chemical assay are a better predictor of decreases in BPRS Psychosis factor scores than RR assayed plasma haloperidol levels or prolactin response to haloperidol.

Author Affiliations
From the Sections of Biological Psychiatry (Drs Smith, Baumgartner, Misra, DeJohn, and Mss Mauldin and Shvartsburd) and Neurochemistry and Neuropsychopharmacology (Dr Ho), Texas Research Institute of Mental Sciences; and the Departments of Psychiatry and Pharmacology, Baylor College of Medicine (Drs Smith and Misra), Houston. Dr DeJohn is now in private practice in Houston.

Footnotes
Accepted for publication Dec 28, 1983.

Reprint requests to Section of Biological Psychiatry, Texas Research Institute of Mental Sciences, 1300 Moursund, Texas Medical Center, Houston, TX 77030 (Dr Smith).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Differential Effects of Atypical Antipsychotics on Prolactin Elevation Are Explained by Their Differential Blood-Brain Disposition: A Pharmacological Analysis in Rats
Kapur et al.
J. Pharmacol. Exp. Ther. 2002;302:1129-1134.
ABSTRACT | FULL TEXT  

Haloperidol Plasma Levels and Dose Optimization
Coryell et al.
Am. J. Psychiatry 1998;155:48-53.
ABSTRACT | FULL TEXT  

Haloperidol Blood Levels and Clinical Effects
Volavka et al.
Arch Gen Psychiatry 1992;49:354-361.
ABSTRACT  

Plasma Haloperidol Levels and Clinical Response
Smith
Arch Gen Psychiatry 1987;44:1110-1112.
ABSTRACT  

Plasma Haloperidol Levels: Clinical Response and Fancy Mathematics
Van Putten et al.
Arch Gen Psychiatry 1985;42:835-835.
ABSTRACT  

The Interpretation of Plasma Haloperidol Concentrations
Kirch et al.
Arch Gen Psychiatry 1985;42:838-839.
ABSTRACT  

The Interpretation of Plasma Haloperidol Concentrations-Reply
Smith
Arch Gen Psychiatry 1985;42:839-840.
ABSTRACT  

Plasma Haloperidol Levels: Clinical Response and Fancy Mathematics-Reply
Smith
Arch Gen Psychiatry 1985;42:835-838.
ABSTRACT