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Jeffrey A. Mattes, MD; Laine Boswell; Herman Oliver, MD

Arch Gen Psychiatry. 1984;41(11):1059-1063.

Abstract
• The objectives of this study were (1) to determine whether attention deficit disorder (ADD) is a specific diagnostic entity in adulthood; (2) to evaluate, using a double-blind crossover design, the efficacy of methylphenidate hydrochloride in adults with evidence of residual ADD with hyperactivity (ADD-H) (N = 26); and (3) to evaluate the specificity of drug response by also administering methylphenidate to patients with similar adult symptoms but no childhood history of ADD-H (N = 35). Results indicated success in differentiating relatively distinct groups. However, no overall benefit from methylphenidate was evident, regardless of childhood history of ADD-H. Approximately 25% of the sample appeared clinically to benefit from methylphenidate, but no clear-cut predictors of drug response were identified; history of drug abuse (polydrug) appeared to be the best predictor. Even among the responders, benefit was generally not as marked nor as clinically valuable as in childhood ADD-H.

Author Affiliations
From the Department of Psychiatry, Hillside Division, Long Island Jewish-Hillside Medical Center, Glen Oaks, NY. Dr Mattes is now with the Carrier Foundation, Belle Mead, NJ.

Footnotes
Accepted for publication March 2, 1984.

Reprint requests to Carrier Foundation, Belle Mead, NJ 08502 (Dr Mattes).

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