Increased Sensitivity to Caffeine in Patients With Panic Disorders: Preliminary Evidence

doi:10.1001/archpsyc.1983.01790220057009

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Vol. 41 No. 11, November 1984

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Increased Sensitivity to Caffeine in Patients With Panic Disorders

Preliminary Evidence

Jean-Philippe Boulenger, MD; Thomas W. Uhde, MD; Edward A. Wolff III; Robert M. Post, MD

Arch Gen Psychiatry. 1984;41(11):1067-1071.

Abstract

• The results of a caffeine consumption inventory indicatedthat patients with panic anxiety disorder, but not affectivelyill patients or normal controls, had levels of self-rated anxietyand depression that correlated with their degree of caffeineconsumption. In addition, this self-report survey suggestedthat patients with panic disorder had an increased sensitivityto the effects of one cup of coffee. This apparent sensitivityto caffeine was also documented by the observation that morepatients with panic disorder reported the discontinuation ofcoffee intake due to untoward side effects than controls. Theseresults, based on self-reports, suggest that the hypothesisthat patients with panic disorder are more reactive to caffeineshould be directly tested using caffeine challenges and thatthe mechanisms underlying caffeine's effects on anxiety shouldbe further explored.

Author Affiliations

From the French National Institute of Health and Medical Research (Dr Boulenger), Caen, France; the Unit on Anxiety and Affective Disorders (Drs Boulenger and Uhde and Mr Wolff), and the Section on Psychobiology (Dr Post), Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.

Footnotes

Accepted for publication Feb 9, 1984.

Read before the 136th annual meeting of the American PsychiatricAssociation, New York, May 3, 1983.

Reprint requests to Unit on Anxiety and Affective Disorders,National Institutes of Health, Bldg 10, Room 3 South 239, 9000Rockville Pike, Bethesda, MD 20205 (Dr Uhde).

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