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A Double-blind, Placebo-Controlled Study

B. Timothy Walsh, MD; Jonathan W. Stewart, MD; Steven P. Roose, MD; Madeline Gladis, MA; Alexander H. Glassman, MD

Arch Gen Psychiatry. 1984;41(11):1105-1109.

Abstract
• Twenty bulimic women of normal weight participated in a double-blind trial studying the effects of a monoamine oxidase inhibitor (MAOI). Nine women received phenelzine sulfate and 11 received placebo. Although phenelzine's side effects were a problem, the phenelzine-treated patients reported significantly fewer binges per week and had a lower Eating Attitudes Test score. Five of the nine phenelzine-treated patients ceased binging entirely and the other four reduced their binge frequency by at least 50%; none of the 11 placebo-treated patients stopped binging and only two reduced their binge frequency by 50% or more. These data demonstrate that phenelzine is significantly more effective than placebo in the treatment of bulimic women of normal weight and suggest a place for MAOIs in the treatment of bulimic patients capable of maintaining a tyramine-free diet.

Author Affiliations
From the Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York.

Footnotes
Accepted for publication June 19, 1984.

Read in part at the Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, Dec 13, 1983.

Reprint requests to New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Walsh).

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