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Platelet 2-Adrenergic Receptor Binding and Plasma Catecholamines

Before and During Imipramine Treatment in Patients With Panic Anxiety

Oliver G. Cameron, MD, PhD; Charles B. Smith, MD, PhD; Peggie J. Hollingsworth, PhD; Randolph M. Nesse, MD; George C. Curtis, MD

Arch Gen Psychiatry. 1984;41(12):1144-1148.

Abstract
• Specific binding of tritiated clonidine, an 2-adrenergic receptor agonist, and tritiated yohimbine, an 2-adrenergic receptor antagonist, to platelet membranes was measured in persons with panic attacks or major depression and in normal subjects. Plasma catecholamine levels were measured in patients with panic attacks and in normal subjects. The number of binding sites in patients with panic attacks, as measured with tritiated clonidine, was lower than in depressed persons and was the same as in normal subjects. The number in patients with panic attacks, as measured with tritiated yohimbine, was lower than in either depressives or normal subjects. Catecholamine levels were somewhat higher in patients with panic attacks than in normal subjects. Treatment with imipramine hydrochloride decreased the number of sites, as measured with either ligand, in both patient groups and increased catecholamine levels in patients with panic attacks.

Author Affiliations
From the Departments of Psychiatry (Drs Cameron, Nesse, and Curtis) and Pharmacology (Drs Smith and Hollingsworth), University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication May 15, 1984.

Read in part before the annual meeting of the American Psychiatric Association, New York City, May 4, 1983.

Reprint requests to Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 (Dr Smith).

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