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Alternative Induction and Crossover Schedules for Methadyl Acetate
Walter Ling, MD;
Walter Dorus, MD;
William A. Hargreaves, PhD;
Richard Resnick, MD;
Edward Senay, MD;
Vicente B. Tuason, MD;
Mara Blakis, MD;
Elaine Holmes, PhD;
C. James Klett, PhD;
Manuel Mejia, MD;
Arthur Weinberg, MD
Arch Gen Psychiatry. 1984;41(2):193-199.
Abstract
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• Various schedules exist for inducting heroin addicts newly admitted to treatment into methadyl acetate maintenance and crossover schedules for the transition from methadone maintenance to methadyl acetate maintenance. A sample of 255 street addicts was randomized to three induction schedules: methadyl acetate three times a week (tiw) with placebos on alternate days; methadyl acetate tiw supplemented with decreasing doses of methadone on alternate days; methadyl acetate six days a week with diminishing doses on three days. Treatment was double-blind for four weeks and single-blind for six. All schedules were considered feasible, but supplementation with methadyl acetate or methadone had no advantage. A sample of 310 patients receiving methadone maintenance was randomized to comparable supplementation groups, except that the group receiving supplementary methadyl acetate received it along with the regular dose. This schedule was not successful. Supplementing with methadone had no advantage.
Author Affiliations
From the Veterans Administration Medical Centers in Sepulveda, Calif (Drs Ling, Blakis, and Holmes), and Perry Point, Md (Dr Klett); the University of Chicago (Drs Dorus and Senay); the University of California, San Francisco (Drs Hargreaves and Weinberg); the St Paul Ramsey Medical Center (Drs Mejia and Tuason); and the New York Medical College, New York City (Dr Resnick).
Footnotes
Accepted for publication Dec 28, 1982.
Reprint requests to Veterans Administration Medical Center, 16111 Plummer St, Sepulveda, CA 91343 (Dr Ling).
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