 |
|
Diazepam and Propranolol in Panic Disorder and Agoraphobia
Russell Noyes, Jr, MD;
Dorothy Jean Anderson, MA;
John Clancy, MD, FRCP(C);
Raymond R. Crowe, MD;
Donald J. Slymen, PhD;
Mohamed M. Ghoneim, MD;
James V. Hinrichs, PhD
Arch Gen Psychiatry. 1984;41(3):287-292.
Abstract
• The response to diazepam and propranolol hydrochloride was compared in 21 patients who (with one exception) met DSM-Ill criteria for panic disorder and agoraphobia. Each drug was administered for two weeks in double-blind fashion according to a crossover design. The response to diazepam was significantly superior on all measures. By observer rating, 18 patients showed at least moderate improvement with diazepam compared with seven receiving propranolol. Panic attacks and phobic symptoms responded to diazepam, but not to propranolol. The results suggest that benzodiazepines constitute effective short-term treatment for these newly defined disorders.
Author Affiliations
From the Departments of Psychiatry (Drs Noyes, Clancy, and Crowe, and Ms Anderson), Preventive Medicine and Environmental Health (Dr Slymen), Anesthesia (Dr Ghoneim), and Psychology (Dr Hinrichs), University of Iowa, College of Medicine, Iowa City.
Footnotes
Accepted for publication June 13, 1983.
Reprint requests to Department of Psychiatry, University of Iowa, College of Medicine, 500 Newton Rd, Iowa City, IA 52242 (Dr Noyes).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Use of Benzodiazepines in Anxiety Disorders
Shader and Greenblatt
NEJM 1993;328:1398-1405.
FULL TEXT
A Comparison of Fluvoxamine, Cognitive Therapy, and Placebo in the Treatment of Panic Disorder
Black et al.
Arch Gen Psychiatry 1993;50:44-50.
ABSTRACT
Effects of selective beta-adrenoceptor blockade on anxiety associated with flight phobia
Ekeberg et al.
J Psychopharmacol 1990;4:35-41.
ABSTRACT
Lactate and Hyperventilation Substantially Attenuate Vagal Tone in Normal Volunteers: A Possible Mechanism of Panic Provocation?
George et al.
Arch Gen Psychiatry 1989;46:153-156.
ABSTRACT
Biphasic effects of propranolol on extinction of rewarded responding
Salmon
J Psychopharmacol 1989;3:83-87.
ABSTRACT
Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter Trial: I. Efficacy in Short-term Treatment
Ballenger et al.
Arch Gen Psychiatry 1988;45:413-422.
ABSTRACT
Lactate Provocation of Panic Attacks: II. Biochemical and Physiological Findings
Liebowitz et al.
Arch Gen Psychiatry 1985;42:709-719.
ABSTRACT
Social Phobia: Review of a Neglected Anxiety Disorder
Liebowitz et al.
Arch Gen Psychiatry 1985;42:729-736.
ABSTRACT
Anxiety in Patients With Pheochromocytomas
Starkman et al.
Arch Intern Med 1985;145:248-252.
ABSTRACT
Considerations in {beta}-Adrenergic Blocker Evaluation
Yudofsky and Silver
Arch Gen Psychiatry 1984;41:1185-1186.
ABSTRACT
|
