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A Positron Emission Transaxial Tomographic Study

Tibor Farkas, MD; Alfred P. Wolf, PhD; Judith Jaeger, MPA; Jonathan D. Brodie, MD, PhD; David R. Christman, PhD; Joanna S. Fowler, PhD; Robert R. MacGregor; Mony J. deLeon, EdD; Philip deFina, MA; Alan Goldman, MD; Yoshihara Yonekura, MD; A. Bertrand Brill, MD, PhD; Melvin Schwartz, PhD; Jean Logan, PhD; Robert Cancro, MD

Arch Gen Psychiatry. 1984;41(3):293-300.

Abstract
• Thirteen diagnosed schizophrenics and 11 normal controls were studied with a method using the PETT III positron emission tomograph (PET) and fluorodeoxyglucose labeled with fluorine 18. Each subject also had a computed tomographic (CT) scan. For each subject, two brain levels, one through the basal ganglia and one through the semioval center, were analyzed for the mean regional metabolic glucose rate. Specifically, relationships between frontal and posterior regions were evaluated. The CT scans of matching levels were superimposed on the functional PET images to provide anatomic criteria for region of interest selection. While no wholeslice metabolic differences were apparent between groups, schizophrenics had significantly lower activity in the frontal lobes, relative to posterior regions. The medicated and drugfree groups did not differ from one another in these regards. Trait v state dependency of the phenomenon was analyzed, and several technological limitations were considered.

Author Affiliations
From New York University Medical Center, New York (Drs Farkas, Brodie, deLeon, Schwartz, and Cancro, Ms Jaeger, and Mr deFina) and the Chemistry Department, Brookhaven National Laboratory, Upton, NY (Drs Wolf, Christman, Fowler, Goldman, Yonekura, Brill, and Logan and Mr MacGregor).

Footnotes
Accepted for publication Sept 19, 1983.

Reprint requests to Department of Chemistry, Brookhaven National Laboratory, Associated Universities, Inc, Upton, NY 11973 (Dr Wolf).

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