Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders: I. Enhanced Response in Depression and Mania

doi:10.1001/archpsyc.1984.01790150056009

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Vol. 41 No. 4, April 1984

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Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders

I. Enhanced Response in Depression and Mania

Herbert Y. Meltzer, MD; Brinda Umberkoman-Wiita, PhD; Alan Robertson, MD; Betty Jo Tricou, MD; Martin Lowy, PhD; Richard Perline, PhD

Arch Gen Psychiatry. 1984;41(4):366-374.

Abstract

• The serum cortisol concentration following administrationof 5-hydroxytryptophan (5-HTP), 200 mg orally, a precursor ofserotonin (5-HT), was significantly greater in unmedicated depressedand manic patients than in normal controls. Increases in serumcortisol levels greater than 5 ug/dL were significantly morefrequent in both unmedicated depressed and manic patients thanin the normal controls. There was significant test-retest reliability.Baseline serum cortisol concentration correlated negativelywith the cortisol response to 5-HTP in normal controls. Theseresults suggest increased 5-HT receptor sensitivity may be present,possibly in the hypothalamus or pituitary, in some patientswith affective disorders. These results are consistent withthe hypothesis that decreased serotonergic activity, which wouldbe expected to produce increased 5-HT receptor sensitivity,may be present in both depression and mania.

Author Affiliations

From the Department of Psychiatry, University of Chicago Pritzker School of Medicine, and the Illinois State Psychiatric Institute, Chicago.

Footnotes

Accepted for publication Sept 23, 1983.

Reprint requests to Department of Psychiatry, University ofChicago Pritzker School of Medicine, 950 E 59th St, Chicago,IL 60637 (Dr Meltzer).

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