This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Final Report on Response to Insulin-Induced Hypoglycemia During a Depressive Episode

Joaquim Puig-Antich, MD; Hana Novacenko, MS; Mark Davies, MPH; William J. Chambers, MD; Mary Ann Tabrizi, RN; Virginia Krawiec; Paul J. Ambrosini, MD; Edward J. Sachar, MD

Arch Gen Psychiatry. 1984;41(5):455-460.

Abstract
• Insulin tolerance tests (ITTs) were carried out on 46 drugfree prepubertal children with severe emotional disorders. Thirteen met unmodified Research Diagnostic Criteria for major depressive disorder, definite endogenous subtype, 17 met the criteria for nonendogenous major depressive disorder, and 16 fit DSM-III criteria for nondepressed neurotic disorders. The group with endogenous depression had significant hyposecretion of growth hormone (GH) in this test when compared with the other groups. Since GH hyposecretion in response to ITT has been found in most studies to be associated with endogenous major depression in adults, the data support the validity of the diagnosis of prepubertal endogenous major depressive disorder and the hypothesis of similarity or identity of prepubertal and adult major depressive disorders.

Author Affiliations
From the Department of Child Psychiatry (Drs Puig-Antich, Chambers, and Ambrosini and Ms Tabrizi), the Sleep/Neuroendocrine Unit, New York State Psychiatric Institute (Drs Puig-Antich and Sachar, Mss Novacenko and Krawiec, and Mr Davies), and the Department of Psychiatry, Columbia University, College of Physicians and Surgeons (Drs Puig-Antich, Chambers, Ambrosini, and Sachar), New York.

Footnotes
Accepted for publication Aug 16, 1983.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Myth of Attention Deficit- Hyperactivity Disorder: Symptoms Resulting from Multiple Causes
Weinberg and Brumback
J Child Neurol 1992;7:431-445.
 

A Controlled Family History Study of Prepubertal Major Depressive Disorder
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:406-418.
ABSTRACT  

Adult Sequelae of Adolescent Depressive Symptoms
Kandel and Davies
Arch Gen Psychiatry 1986;43:255-262.
ABSTRACT  

Psychosocial Functioning in Prepubertal Major Depressive Disorders: I. Interpersonal Relationships During the Depressive Episode
Puig-Antich et al.
Arch Gen Psychiatry 1985;42:500-507.
ABSTRACT  

Growth Hormone Secretion in Prepubertal Children With Major Depression: IL Sleep-Related Plasma Concentrations During a Depressive Episode
Puig-Antich et al.
Arch Gen Psychiatry 1984;41:463-466.
ABSTRACT  

Growth Hormone Secretion in Prepubertal Children With Major Depression: III. Response to Insulin-Induced Hypoglycemia After Recovery From a Depressive Episode and in a Drug-Free State
Puig-Antich et al.
Arch Gen Psychiatry 1984;41:471-475.
ABSTRACT  

Growth Hormone Secretion in Prepubertal Children With Major Depression: IV. Sleep-Related Plasma Concentrations in a Drug-Free, Fully Recovered Clinical State
Puig-Antich et al.
Arch Gen Psychiatry 1984;41:479-483.
ABSTRACT