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IV. Sleep-Related Plasma Concentrations in a Drug-Free, Fully Recovered Clinical State

Joaquim Puig-Antich, MD; Raymond Goetz, PhD; Mark Davies, MPH; Mary Ann Tabrizi, RN; Hana Novacenko, MS; Cleo Hanlon, MS; Edward J. Sachar, MD; Elliot D. Weitzman, MD

Arch Gen Psychiatry. 1984;41(5):479-483.

Abstract
Prepubertal children with major depressive disorder have shown Increased growth hormone (GH) secretion during sleep while in a depressive episode. When restudied in a fully recovered state (for at least three months) and drug free (for at least one month), their increased GH secretory pattern during sleep had not changed. Illness-recovery correlations using area under the curve for GH secretion during sleep were highly significant, whereas paired comparisons showed no significant differences. In addition, children who had recovered from major depressive episodes secreted significantly more GH during sleep than did nondepressed neurotic and normal children. No significant differences in o-sleep were found in the depressed group between ill and recovered states nor among those who had recovered from major depressive episodes or controls. It is concluded that increased GH secretion during sleep is independent of depressive episodes, remains unaltered after full recovery, and may be a true marker of trait for major depressive disorder in prepuberty.

Author Affiliations
From the Department of Child Psychiatry (Dr Puig-Antich and Ms Tabrizi) and the Sleep/Neuroendocrine Unit (Drs Puig-Antich, Sachar, and Goetz, Mss Novacenko and Hanlon, and Mr Davies), New York State Psychiatric Institute, and the Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York (Drs Puig-Antich, Goetz, and Sachar), and the Institute of Chronobiology, New York Hospital-Cornell Medical Center (Westchester Division), White Plains, NY (Dr Weitzman).

Footnotes
Accepted for publication Aug 16, 1983.

Reprints not available.

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