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A Comparison in Hospitalized Aggressive Children With Conduct Disorder

Magda Campbell, MD; Arthur M. Small, MD; Wayne H. Green, MD; Susan J. Jennings, MA; Richard Perry, MD; Walter G. Bennett, MD; Lillian Anderson, RN

Arch Gen Psychiatry. 1984;41(7):650-656.

Abstract
• The efficacy and safety of haloperidol, lithium carbonate, and placebo were critically assessed in 61 treatment-resistant, hospitalized children aged 5.2 to 12.9 years with diagnoses of conduct disorder, aggressive type. In this double-blind and well-controlled study, the optimal dosages of haloperidol ranged from 1.0 to 6.0 mg/day and those of lithium carbonate from 500 to 2,000 mg/day. For the assessment of behavioral changes and untoward effects, various rating scales were used in different settings. Both haloperidol and lithium carbonate were found to be significantly superior to placebo in decreasing behavioral symptoms. Although both medications were clinically effective, haloperidol was associated more often with untoward effects than was lithium carbonate.

Author Affiliations
From the Department of Psychiatry, New York University Medical Center, New York.

Footnotes
Accepted for publication Sept 18, 1983.

Deceased.

Read at the 20th annual meeting of the American College of Neuropsychopharmacology, San Diego, Dec 18, 1981.

Reprint requests to Department of Psychiatry, New York University Medical Center, 550 First Ave, New York, NY 10016 (Dr Campbell).

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