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Cognitive Effects of Lithium Carbonate and Haloperidol in Treatment-Resistant Aggressive Children
Jane E. Platt, PhD;
Magda Campbell, MD;
Wayne H. Green, MD;
Dennis M. Grega, PhD
Arch Gen Psychiatry. 1984;41(7):657-662.
Abstract
• The effects of lithium carbonate and haloperidol on cognition were examined in a placebo-controlled, double-blind study of 61 treatment-resistant, hospitalized school-aged children. They all had a DSM-III diagnosis of conduct disorder— undersocialized, aggressive, with a profile of highly explosive and aggressive behavior. Children were assessed at the end of a two-week placebo-baseline period and again after four weeks of treatment. Drug effects on cognition were mild. Haloperidol (mean dose, 2.95 mg/day) caused significant decreases in Porteus Maze test quotient scores and a slowing of reaction time (RT) on a simple RT task. Lithium carbonate (mean dose, 1,166 mg/day) adversely affected qualitative scores on the Porteus Maze test. No significant treatment effects were found for the Matching Familiar Figures Test, short-term recognition memory and concept attainment tasks, or the Stroop Test.
Author Affiliations
From the Department of Psychiatry, New York University Medical Center.
Footnotes
Accepted for publication Nov 15, 1983.
Read before the annual meeting of the National Institute of Mental Health-New Clinical Drug Evaluation Unit, Key Biscayne, Fla, June 2, 1983.
Reprint requests to Department of Psychiatry, New York University Medical Center, 550 First Ave, New York, NY 10016 (Dr Platt).
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