You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 41 No. 8, August 1984 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL ARTICLES
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

A Search for Cytomegalovirus and Herpes Viral Antigen in Brains of Schizophrenic Patients

Janice R. Stevens, MD; John M. Langloss, DVM, PhD; Paul Albrecht, MD; Robert Yolken, MD; Yen-Nung Wang, MD

Arch Gen Psychiatry. 1984;41(8):795-801.


Abstract

• The peroxidase-antiperoxidase method was employed to search for evidence of cytomegalovirus (CMV) or herpes simplex virus (HSV) antigen in the brains of 25 patients with a diagnosis of schizophrenia, 25 nonschizophrenic neuropsychiatric patients, and 16 nonpsychiatric control subjects. Brain specimens from patients with acute CMV and herpes encephalitis served as positive controls. Although early results with low-titer CMV antisera suggested immunoreactivity in specific brain regions of a small number of schizophrenic and control cases, the present studies with high-titer anti-CMV IgG did not give a positive immunoperoxidase reaction in sections from the basal forebrain, hypothalamus, or midbrain. Scattered neurons in the lateral vestibular nucleus and hippocampus showed questionable staining with CMV IgG in one schizophrenic patient and none in control subjects. No schizophrenic or control cases demonstrated an immune reaction to HSV antisera.



Author Affiliations

From the National Institute of Mental Health (NIMH), St Elizabeths Hospital, Washington, DC (Drs Stevens and Wang); The Oregon Health Sciences University, Portland (Dr Stevens); the Armed Forces Institute of Pathology, Walter Reed Hospital, Washington, DC (Dr Langloss); the National Institutes of Health, Washington, DC (Dr Albrecht); and The Johns Hopkins Hospital and Medical School, Baltimore (Dr Yolken).


Footnotes

Accepted for publication Jan 30, 1984.

Reprint requests to NIMH, Division of Special Mental Health Research, IR, St Elizabeths WAW Building, Washington, DC 20032 (Dr Stevens).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Results From a Hypothesis Generating Case-Control Study: Herpes Family Viruses and Schizophrenia Among Military Personnel
Niebuhr et al.
Schizophr Bull 2008;34:1182-1188.
ABSTRACT | FULL TEXT  

Search for Viral Nucleic Acid Sequences in Brain Tissues of Patients With Schizophrenia Using Nested Polymerase Chain Reaction
Taller et al.
Arch Gen Psychiatry 1996;53:32-40.
ABSTRACT  

Search for Cytomegalovirus in the Postmortem Brains of Schizophrenic Patients Using the Polymerase Chain Reaction
Alexander et al.
Arch Gen Psychiatry 1992;49:47-53.
ABSTRACT  

Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
Mednick et al.
Arch Gen Psychiatry 1988;45:189-192.
ABSTRACT  

Borna Disease Virus: A Possible Etiologic Factor in Human Affective Disorders?
Amsterdam et al.
Arch Gen Psychiatry 1985;42:1093-1096.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1984 American Medical Association. All Rights Reserved.