This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Michael C. Rowbotham, MD; Reese T. Jones, MD; Neal L. Benowitz, MD; Peyton Jacob III, PhD

Arch Gen Psychiatry. 1984;41(9):895-899.

Abstract
• Depression and dysphoria can follow the long-term use of cocaine. Little is known about the interaction of antidepressant drugs with cocaine and similar stimulants in humans. The physiologic and subjective effects of an oral 2-mg/kg dose of cocaine hydrochloride were measured in eight healthy cocaine-using men after pretreatment with a single, 100-mg oral dose of the triazolopyridine antidepressant trazodone hydrochloride or placebo in a double-blind study. The cocaineinduced effects of increased BP, increased pupil size, and decreased skin temperature were diminished by trazodone pretreatment. Trazodone alone did not alter plasma epinephrine or norepinephrine levels. An increase in plasma epinephrine levels after cocaine administration was not altered by trazodone pretreatment, but the increase in the norepinephrine level was larger. Trazodone alone produced mild sleepiness. Cocaine-induced euphoria was not altered by trazodone pretreatment, although feelings of tension and shakiness after cocaine administration were diminished.

Author Affiliations
From the Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco.

Footnotes
Accepted for publication Jan 10, 1984.

Reprint requests to Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143 (Dr Jones).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Attenuation of the Euphoric Effects of Cocaine by the Dopamine D1/D5 Antagonist Ecopipam (SCH 39166)
Romach et al.
Arch Gen Psychiatry 1999;56:1101-1106.
ABSTRACT | FULL TEXT  

Trazodone and Cocaine Abuse
Small and Purcell
Arch Gen Psychiatry 1985;42:524-524.
ABSTRACT  

Cocaine Abuse Treatment: Open Pilot Trial With Desipramine and Lithium Carbonate
Gawin and Kleber
Arch Gen Psychiatry 1984;41:903-909.
ABSTRACT