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A Double-blind Controlled Study

Martine F. Flament, MD; Judith L. Rapoport, MD; Carol J. Berg, MA; Walter Sceery, MSW; Clinton Kilts, PhD; Britt Mellström, PhD; Markku Linnoila, MD, PhD

Arch Gen Psychiatry. 1985;42(10):977-983.

Abstract
• Nineteen children (mean [±SD] age, 14.5±2.3 years) with severe, primary obsessive-compulsive disorder completed a ten-week, double-blind, controlled trial of clomipramine hydrochloride (mean dosage, 141 mg/day) or placebo, each of which was administered for five weeks. Half of the subjects had not responded to previous treatment with other tricyclic antidepressants. There was a significant improvement in observed and self-reported obsessions and compulsions that was independent of the presence of depressive symptoms at baseline. Improvement in obsessive-compulsive symptoms did not correlate significantly with plasma concentrations of the drug or its metabolites. Clomipramine appears to be effective in the treatment of children with obsessive-compulsive disorder and the treatment seems to be independent of an antidepressant effect.

Author Affiliations
From the Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md (Drs Flament and Rapoport, Ms Berg, and Mr Sceery); the Clinical Psychopharmacology Section, Department of Psychiatry, Duke University Medical Center, Durham, NC (Dr Kilts); the Department of Clinical Pharmacology, Huddinge University Hospital, Huddinge, Sweden (Dr Mellström); and the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda (Dr Linnoila).

Footnotes
Accepted for publication Jan 7, 1985.

Reprint requests to Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 6N-240, 9000 Rockville Pike, Washington, DC 20205-1000 (Dr Rapoport).

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