You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 42 No. 10, October 1985 TABLE OF CONTENTS
  Archives
  •  Online Features
  ORIGINAL ARTICLES
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati
What's this?

Affective Disorders in Referred Children and Younger Siblings of Manic-Depressives

Mode of Onset and Prospective Course

Hagop S. Akiskal, MD; John Downs, MD; Patti Jordan, PharmD; Sally Watson, RN; David Daugherty, MD; David B. Pruitt, MD

Arch Gen Psychiatry. 1985;42(10):996-1003.


Abstract

• We studied 68 referred juvenile offspring or siblings of adult bipolar patients. Mean age at onset of affective and related disturbances was 15.9 years (range, 6 to 24 years). Although four of the ten prepubertal children had hypomanic features, full-blown manic psychosis did not appear before puberty. In the sample at large, 12 were classified as dysthymic and ten as cyclothymic. Eleven additional subjects with polysubstance abuse, who at onset did not meet criteria for affective disorder, were reclassified as having either a dysthymic or a cyclothymic disorder during follow-up. Of the remaining patients—24 depressive, eight manic, and three mixed state—71% experienced recurrences; mood-incongruent features, present in four cases at onset, recurred in only one patient during subsequent episodes. Overall, half the sample evidenced signs of bipolarity during a mean prospective follow-up period of three years.



Author Affiliations

From the Affective Disorders Program, the Departments of Psychiatry and Pharmacology (Dr Akiskal), and the Child and Adolescent Division (Drs Daugherty and Pruitt), the University of Tennessee College of Medicine, Memphis; and the Mood Clinic, Northeast Mental Health Center, Memphis (Drs Akiskal, Downs, and Jordan, and Ms Watson).


Footnotes

Accepted for publication Feb 25, 1985.

Reprint requests to Department of Psychiatry, University of Tennessee, 66 N Pauline St, Suite 633, Memphis, TN 38163 (Dr Akiskal).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Review of Mood Disorders Among Juvenile Offenders
Ryan and Redding
Psychiatr. Serv. 2004;55:1397-1407.
ABSTRACT | FULL TEXT  

Affective Illness in Children and Adolescents: Patterns of Presentation in Relation to Pubertal Maturation and Family History
Schraufnagel et al.
J Child Neurol 2001;16:553-561.
ABSTRACT  

Auditory Hallucinations in Nonpsychotic Children With Affective Syndromes and Migraines: Report of 13 Cases
Schreier
J Child Neurol 1998;13:377-382.
ABSTRACT  

Switching From 'Unipolar' to Bipolar II: An 11-Year Prospective Study of Clinical and Temperamental Predictors in 559 Patients
Akiskal et al.
Arch Gen Psychiatry 1995;52:114-123.
ABSTRACT  

Childhood-Onset Dysthymic Disorder: Clinical Features and Prospective Naturalistic Outcome
Kovacs et al.
Arch Gen Psychiatry 1994;51:365-374.
ABSTRACT  

The Myth of Attention Deficit- Hyperactivity Disorder: Symptoms Resulting from Multiple Causes
Weinberg and Brumback
J Child Neurol 1992;7:431-445.
 

Attention Deficit Hyperactivity Disorder: The Differential Diagnosis
Weinberg and Emslie
J Child Neurol 1991;6:S23-S36.
ABSTRACT  

Cortisol Secretion in Prepubertal Children With Major Depressive Disorder: Episode and Recovery
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:801-809.
ABSTRACT  

A Controlled Family History Study of Prepubertal Major Depressive Disorder
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:406-418.
ABSTRACT  

Increased Activity and Phase Delay in Circadian Motility Rhythms in Geriatric Depression: Preliminary Observations
Teicher et al.
Arch Gen Psychiatry 1988;45:913-917.
ABSTRACT  

The Clinical Picture of Major Depression in Children and Adolescents
Ryan et al.
Arch Gen Psychiatry 1987;44:854-861.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1985 American Medical Association. All Rights Reserved.