Affective Disorders in Referred Children and Younger Siblings of Manic-Depressives: Mode of Onset and Prospective Course

doi:10.1001/archpsyc.1985.01790330076009

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 42 No. 10, October 1985

Online Only
	•	Online First Table of Contents

ORIGINAL ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (238)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Affective Disorders in Referred Children and Younger Siblings of Manic-Depressives

Mode of Onset and Prospective Course

Hagop S. Akiskal, MD; John Downs, MD; Patti Jordan, PharmD; Sally Watson, RN; David Daugherty, MD; David B. Pruitt, MD

Arch Gen Psychiatry. 1985;42(10):996-1003.

Abstract

• We studied 68 referred juvenile offspring or siblingsof adult bipolar patients. Mean age at onset of affective andrelated disturbances was 15.9 years (range, 6 to 24 years).Although four of the ten prepubertal children had hypomanicfeatures, full-blown manic psychosis did not appear before puberty.In the sample at large, 12 were classified as dysthymic andten as cyclothymic. Eleven additional subjects with polysubstanceabuse, who at onset did not meet criteria for affective disorder,were reclassified as having either a dysthymic or a cyclothymicdisorder during follow-up. Of the remaining patients—24depressive, eight manic, and three mixed state—71% experiencedrecurrences; mood-incongruent features, present in four casesat onset, recurred in only one patient during subsequent episodes.Overall, half the sample evidenced signs of bipolarity duringa mean prospective follow-up period of three years.

Author Affiliations

From the Affective Disorders Program, the Departments of Psychiatry and Pharmacology (Dr Akiskal), and the Child and Adolescent Division (Drs Daugherty and Pruitt), the University of Tennessee College of Medicine, Memphis; and the Mood Clinic, Northeast Mental Health Center, Memphis (Drs Akiskal, Downs, and Jordan, and Ms Watson).

Footnotes

Accepted for publication Feb 25, 1985.

Reprint requests to Department of Psychiatry, University ofTennessee, 66 N Pauline St, Suite 633, Memphis, TN 38163 (DrAkiskal).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A High-Risk Study of Bipolar Disorder: Childhood Clinical Phenotypes as Precursors of Major Mood Disorders
Nurnberger et al.
Arch Gen Psychiatry 2011;68:1012-1020.
ABSTRACT | FULL TEXT

Early course of bipolar disorder in high-risk offspring: prospective study
Duffy et al.
Br. J. Psychiatry 2009;195:457-458.
ABSTRACT | FULL TEXT

Growing Evidence to Support Early Intervention in Early Onset Bipolar Disorder
Mao and Findling
Aust N Z J Psychiatry 2007;41:633-636.
FULL TEXT

Pharmacological Treatment in the Early Phase of Bipolar Disorders: What Stage are we at?
Conus et al.
Aust N Z J Psychiatry 2006;40:199-207.
ABSTRACT | FULL TEXT

Affective Illness in Children and Adolescents: Patterns of Presentation in Relation to Pubertal Maturation and Family History
Schraufnagel et al.
J Child Neurol 2001;16:553-561.
ABSTRACT

Auditory Hallucinations in Nonpsychotic Children With Affective Syndromes and Migraines: Report of 13 Cases
Schreier
J Child Neurol 1998;13:377-382.
ABSTRACT

Switching From 'Unipolar' to Bipolar II: An 11-Year Prospective Study of Clinical and Temperamental Predictors in 559 Patients
Akiskal et al.
Arch Gen Psychiatry 1995;52:114-123.
ABSTRACT

Childhood-Onset Dysthymic Disorder: Clinical Features and Prospective Naturalistic Outcome
Kovacs et al.
Arch Gen Psychiatry 1994;51:365-374.
ABSTRACT

The Myth of Attention Deficit- Hyperactivity Disorder: Symptoms Resulting from Multiple Causes
Weinberg and Brumback
J Child Neurol 1992;7:431-445.

Attention Deficit Hyperactivity Disorder: The Differential Diagnosis
Weinberg and Emslie
J Child Neurol 1991;6:S23-S36.
ABSTRACT

Cortisol Secretion in Prepubertal Children With Major Depressive Disorder: Episode and Recovery
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:801-809.
ABSTRACT

A Controlled Family History Study of Prepubertal Major Depressive Disorder
Puig-Antich et al.
Arch Gen Psychiatry 1989;46:406-418.
ABSTRACT

Increased Activity and Phase Delay in Circadian Motility Rhythms in Geriatric Depression: Preliminary Observations
Teicher et al.
Arch Gen Psychiatry 1988;45:913-917.
ABSTRACT

The Clinical Picture of Major Depression in Children and Adolescents
Ryan et al.
Arch Gen Psychiatry 1987;44:854-861.
ABSTRACT

| | |