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Lymphocyte Function in Ambulatory Depressed Patients, Hospitalized Schizophrenic Patients, and Patients Hospitalized for Herniorrhaphy

Steven J. Schleifer, MD; Steven E. Keller, PhD; Samuel G. Siris, MD; Kenneth L. Davis, MD; Marvin Stein, MD

Arch Gen Psychiatry. 1985;42(2):129-133.

Abstract
• Mitogen-induced lymphocyte stimulation responses in ambulatory patients with major depressive disorder did not differ from those of matched controls. Lymphocyte responses in hospitalized schizophrenic patients and in patients hospitalized for elective herniorrhaphy similarly did not differ from responses of controls. The number of peripheral-blood T cells was decreased among the ambulatory depressed patients but not in the schizophrenic patients. These findings, together with previously reported decreased lymphocyte function in hospitalized depressed patients, suggest that decreased lymphocyte function is associated specifically with depression and not related to hospital effects or nonspecifically to other psychiatric disorders. The results also suggest that altered immunity in depression may be related to severity of depressive symptoms.

Author Affiliations
From the Department of Psychiatry, Mount Sinai School of Medicine, City University of New York.

Footnotes
Accepted for publication July 16, 1984.

Reprint requests to Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L. Levy Pl, New York, NY 10029 (Dr Schleifer).

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