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Atrophy Limited to the Third Ventricle in Chronic Schizophrenic PatientsReport of a Controlled Series
John Boronow, MD;
David Pickar, MD;
Philip T. Ninan, MD;
Alec Roy, MB;
Daniel Hommer, MD;
Markku Linnoila, MD;
Steven M. Paul, MD
Arch Gen Psychiatry. 1985;42(3):266-271.
Abstract
• Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.
Author Affiliations
From the Sheppard-Pratt Hospital, Towson, Md (Dr Boronow); the Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Md (Drs Pickar, Roy, Hommer, and Paul); Emory University Clinic, Atlanta (Dr Ninan); and the National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md (Dr Linnoila).
Footnotes
Accepted for publication June 13, 1984.
Reprint requests to National Institute of Mental Health, Bldg 10, Room 4N214, Bethesda, MD 20205 (Dr Pickar).
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