This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Report of a Controlled Series

John Boronow, MD; David Pickar, MD; Philip T. Ninan, MD; Alec Roy, MB; Daniel Hommer, MD; Markku Linnoila, MD; Steven M. Paul, MD

Arch Gen Psychiatry. 1985;42(3):266-271.

Abstract
• Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.

Author Affiliations
From the Sheppard-Pratt Hospital, Towson, Md (Dr Boronow); the Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Md (Drs Pickar, Roy, Hommer, and Paul); Emory University Clinic, Atlanta (Dr Ninan); and the National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md (Dr Linnoila).

Footnotes
Accepted for publication June 13, 1984.

Reprint requests to National Institute of Mental Health, Bldg 10, Room 4N214, Bethesda, MD 20205 (Dr Pickar).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Progressive Loss of Cerebellar Volume in Childhood-Onset Schizophrenia
Keller et al.
Am. J. Psychiatry 2003;160:128-133.
ABSTRACT | FULL TEXT  

Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers: I. Contributions of Genetic and Perinatal Factors
Cannon et al.
Arch Gen Psychiatry 1993;50:551-564.
ABSTRACT  

Ventricular Enlargement in Schizophrenia Evaluated With Computed Tomographic Scanning: Effects of Gender, Age, and Stage of Illness
Andreasen et al.
Arch Gen Psychiatry 1990;47:1008-1015.
ABSTRACT  

Genetic and Perinatal Determinants of Structural Brain Deficits in Schizophrenia
Cannon et al.
Arch Gen Psychiatry 1989;46:883-889.
ABSTRACT  

Computed Tomographic Evidence for Generalized Sulcal and Ventricular Enlargement in Schizophrenia
Pfefferbaum et al.
Arch Gen Psychiatry 1988;45:633-640.
ABSTRACT  

Quantitative Neuroanatomy in Schizophrenia: A Controlled Magnetic Resonance Imaging Study
Kelsoe et al.
Arch Gen Psychiatry 1988;45:533-541.
ABSTRACT  

CT Scan and MRI Findings in a Child With Schizophrenia
Woody et al.
J Child Neurol 1987;2:105-110.
ABSTRACT  

Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics
Wong et al.
Science 1986;234:1558-1563.
ABSTRACT  

Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients: Correlation With Psychosis and Response to Neuroleptic Treatment
Pickar et al.
Arch Gen Psychiatry 1986;43:669-676.
ABSTRACT