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Dexamethasone Suppression Test and Familial Subtypes of Depression

Mark Zimmerman; William Coryell, MD; Bruce M. Pfohl, MD

Arch Gen Psychiatry. 1985;42(3):300-304.

Abstract
• A sample of 184 hospitalized primary unipolar depressives was used to examine the relationship between the dexamethasone suppression test (DST) and Winokur's familial typology as a function of the broadness of the criteria used to diagnose the patients' first-degree relatives. When a high threshold was used (ie, alcoholic relatives were treated, antisocial relatives had legal problems, and depressed relatives were hospitalized), the DST—familial subtype relationship was much stronger than when a low threshold was used (ie, relatives were diagnosed according to the Family History Research Diagnostic Criteria). The differences in diagnosing family members may be responsible for the inconsistent results reported by investigators examining the relationship between Winokur's typology and the DST.

Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.

Footnotes
Accepted for publication May 11, 1984.

Reprint requests to Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Rd, Iowa City, IA 52242 (Mr Zimmerman).

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