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Studies With Positron Emission Tomography and Fluorodeoxyglucose F 18

Lewis R. Baxter, Jr, MD; Michael E. Phelps, PhD; John C. Mazziotta, MD, PhD; Jeffrey M. Schwartz, MD; Robert H. Gerner, MD; Carl E. Selin, MS; Ron M. Sumida

Arch Gen Psychiatry. 1985;42(5):441-447.

Abstract
• Cerebral metabolic rates for glucose were examined in patients with unipolar depression (N=11), bipolar depression (N=5), mania (N=5), bipolar mixed states (N =3), and in normal controls (N = 9) using positron emission tomography and fluorodeoxyglucose F 18. All subjects were studied supine under ambient room conditions with eyes open. Bipolar depressed and mixed patients had supratentorial whole brain glucose metabolic rates that were significantly lower than those of the other comparison groups. The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state. Patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole, when compared with normal controls and patients with bipolar depression.

Author Affiliations
From the Division of Biophysics and Nuclear Medicine, Department of Radiological Sciences (Drs Baxter, Phelps, Mazziotta, and Messrs Selin and Sumida); Departments of Psychiatry (Drs Baxter, Schwartz, and Gerner) and Neurology (Dr Mazziotta), UCLA.

Footnotes
Accepted for publication Sept 10, 1984.

Read in part before the 137th annual meeting of the American Psychiatric Association, Los Angeles, May 11, 1984.

Reprint requests to UCLA Neuropsychiatric Institute, 760 Westwood Pl, Los Angeles, CA 90024 (Dr Baxter).

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