This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Resting Cerebral Glucose Utilization Rates as Measured With Positron Emission Tomography

Judith M. Rumsey, PhD; Ranjan Duara, MD; Cheryl Grady, PhD; Judith L. Rapoport, MD; Richard A. Margolin, MD; Stanley I. Rapoport, MD; Neal R. Cutler, MD

Arch Gen Psychiatry. 1985;42(5):448-455.

Abstract
• The cerebral metabolic rate for glucose was studied in ten men ( age=26 years) with well-documented histories of infantile autism and in 15 age-matched normal male controls using positron emission tomography and (F-18) 2-fluoro-2-deoxy-D-glucose. Positron emission tomography was completed during rest, with reduced visual and auditory stimulation. While the autistic group as a whole showed significantly elevated glucose utilization in widespread regions of the brain, there was considerable overlap between the two groups. No brain region showed a reduced metabolic rate in the autistic group. Significantly more autistic, as compared with control, subjects showed extreme relative metabolic rates (ratios of regional metabolic rates to whole brain rates and asymmetries) in one or more brain regions.

Author Affiliations
From the Child Psychiatry Branch, National Institute of Mental Health (Drs Rumsey and J. L. Rapoport); Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging (Drs Duara, Grady, S. I. Rapoport, and Cutler); and the Department of Nuclear Medicine, Clinical Center, National Institutes of Health (Dr Margolin), Bethesda, Md.

Footnotes
Accepted for publication Sept 11, 1984.

Reprint requests to Child Psychiatry Branch, National Institute of Mental Health, Bldg 10, Room 6N-240, 9000 Rockville Pike, Bethesda, MD 20205 (Dr Rumsey).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Volumetric Analysis and Three-Dimensional Glucose Metabolic Mapping of the Striatum and Thalamus in Patients With Autism Spectrum Disorders
Haznedar et al.
Am. J. Psychiatry 2006;163:1252-1263.
ABSTRACT | FULL TEXT  

Neuroimaging in Disorders of Social and Emotional Functioning: What Is the Question?
Herbert
J Child Neurol 2004;19:772-784.
ABSTRACT  

Temporal Lobe Dysfunction in Childhood Autism: A PET Study
Zilbovicius et al.
Am. J. Psychiatry 2000;157:1988-1993.
ABSTRACT | FULL TEXT  

Limbic Circuitry in Patients With Autism Spectrum Disorders Studied With Positron Emission Tomography and Magnetic Resonance Imaging
Haznedar et al.
Am. J. Psychiatry 2000;157:1994-2001.
ABSTRACT | FULL TEXT  

SPECT Findings in Mentally Retarded Autistic Individuals
Starkstein et al.
J. Neuropsychiatry Clin. Neurosi. 2000;12:370-375.
ABSTRACT | FULL TEXT  

Hypothesis III: Tourette Syndrome Is Only One of Several Causes of a Developmental Basal Ganglia Syndrome
Palumbo et al.
Arch Neurol 1997;54:475-483.
ABSTRACT  

The Neurobiology of Infantile Autism
Ciaranello and Ciaranello
Neuroscientist 1995;1:361-367.
ABSTRACT  

Neuroimaging in Infantile Autism
Schifter et al.
J Child Neurol 1994;9:155-161.
ABSTRACT  

Cerebral Blood Flow and Oxygen Metabolism in Rett Syndrome
Yoshikawa et al.
J Child Neurol 1991;6:237-242.
ABSTRACT  

Diagnostic and Assessment Issues Related to Pharmacotherapy for Children and Adolescents with Autism
Campbell et al.
Behav Modif 1991;15:326-354.
ABSTRACT  

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics: A Pilot Study of the Dorsal Prefrontal Cortex by In Vivo Phosphorus 31 Nuclear Magnetic Resonance Spectroscopy
Pettegrew et al.
Arch Gen Psychiatry 1991;48:563-568.
ABSTRACT  

The Cerebral Metabolic Landscape in Autism: Intercorrelations of Regional Glucose Utilization
Horwitz et al.
Arch Neurol 1988;45:749-755.
ABSTRACT  

Teaching Tips from a Recovered Autistic
Grandin
Focus Autism Other Dev Disabl 1988;3:1-8.
 

Thought, Language, Communication, and Affective Flattening in Autistic Adults
Rumsey et al.
Arch Gen Psychiatry 1986;43:771-777.
ABSTRACT