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A Replication Analysis

Joseph Marcus, MD; Sydney L. Hans, PhD; Sarnoff A. Mednick, MD, PhD; Fini Schulsinger, MD; Niels Michelsen, MD

Arch Gen Psychiatry. 1985;42(8):753-761.

Abstract
• Neurological functioning was compared in children at risk for schizophrenia from samples recruited in Israel and Denmark. In both samples neurological signs were assessed in school-age children with one schizophrenic parent and a matched group of children with no mentally ill parents. Multidimensional Scalogram Analysis of data identified, in both samples, a radex structure of neurological functioning, radiating from motor to sensory-perceptual signs. In both samples, the gradient of neurological functioning differed between the offspring of schizophrenics and controls. For both the offspring of schizophrenics and controls, the largest number of children showed no or few signs of neurological dysfunctioning. A subgroup of the offspring of schizophrenics, but not the controls, showed multiple signs of neurological dysfunctioning that varied in pattern among individuals.

Author Affiliations
From the Department of Psychiatry, University of Chicago (Drs Marcus and Hans); the Social Science Research Institute and Department of Psychology, University of Southern California, Los Angeles (Dr Mednick); Department of Psychiatry, University of Copenhagen (Dr Schulsinger); Psykologisk Institut, Kommunehospitalet, Copenhagen (Drs Mednick, Schulsinger, and Michelsen); and the Unit for Prospective Pediatric Studies, University Hospital, Copenhagen (Dr Michelsen).

Footnotes
Accepted for publication July 16, 1984.

Reprint requests to Department of Psychiatry, Box 411, 5841 S Maryland Ave, Chicago, IL 60637 (Dr Marcus).

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