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  Vol. 42 No. 8, August 1985 TABLE OF CONTENTS
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Basal Ganglia and Limbic System Pathology in Schizophrenia

A Morphometric Study of Brain Volume and Shrinkage

Bernhardt Bogerts, MD; Elisabeth Meertz; Regina Schönfeldt-Bausch

Arch Gen Psychiatry. 1985;42(8):784-791.


Abstract

• The volume of several parts of the basal ganglia and of the limbic system was measured by planimetry of myelin-stained serial sections in postmortem brains of 13 schizophrenic patients and nine control cases. The medial limbic structures of the temporal lobe (amygdala, hippocampal formation, and parahippocampal gyrus) and the pallidum internum were significantly smaller in the schizophrenic group, whereas the pallidum externum showed only a modest trend toward volume reduction. The volumes of the putamen, nucleus caudatus, nucleus accumbens, and the bed nucleus of the stria terminalis did not differ between patients and controls. The volume reductions of the limbic temporal structures and of the pallidum internum of schizophrenics are interpreted as degenerative shrinkages of unknown etiology.



Author Affiliations

From the C. & O. Vogt Institute of Brain Research, University of Düsseldorf, Düsseldorf, Federal Republic of Germany.


Footnotes

Accepted for publication April 12, 1984.

Reprint requests to Department of Psychiatry, University of Dusseldorf, Postfach 120510 Bergische Landtrasse 2, 4000 Düsseldorf 12, Federal Republic of Germany (Dr Bogerts).



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