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Philip D. Kanof, MD, PhD; Celeste Johns, MD; Michael Davidson, MD; Larry J. Siever, MD; Emil F. Coccaro, MD; Kenneth L. Davis, MD

Arch Gen Psychiatry. 1986;43(10):987-993.

Abstract
• The cyclic adenosine monophosphate (cAMP) responses to prostaglandin E₁ (PGE_,) in platelets and leukocytes from drug-free schizophrenic patients, depressive patients, and normal controls have been compared. Both schizophrenic and depressive patients had a significantly lower platelet cAMP response to PGE₁ than controls. The platelet cAMP response to PGE, did not discriminate among exacerbated, remitted, and poor-prognosis schizophrenic patients, or between exacerbated and remitted depressive patients. The cAMP response to PGE₁ was negatively correlated with global symptom severity in actively ill schizophrenic patients, but was not correlated with symptom severity in exacerbated depressive patients. The leukocyte cAMP response to PGE₁ did not differ among normal controls, schizophrenic patients, and depressive patients. These data indicate that a diminished platelet cAMP response to PGE₁ may be a marker common to both schizophrenia and depression but that this effect does not extend to a cAMP-linked PGE₁ receptor on another blood cell type.

Author Affiliations
From the Departments of Psychiatry (Drs Kanof, Johns, Davidson, Siever, Coccaro, and Davis) and Pharmacology (Dr Davis), Mount Sinai School of Medicine, New York; and the Veterans Administration Medical Center, Bronx, NY (Drs Kanof, Johns, Davidson, Siever, Coccaro, and Davis).

Footnotes
Accepted for publication April 23, 1986.

Reprint requests to Veterans Administration Medical Center, Psychiatry Service (116A), 130 W Kingsbridge Rd, Bronx, NY 10468 (Dr Kanof).

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