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Validity of Familial Subtypes of Primary Unipolar DepressionClinical, Demographic, and Psychosocial Correlates
Mark Zimmerman;
William Coryell, MD;
Bruce Pfohl, MD
Arch Gen Psychiatry. 1986;43(11):1090-1096.
Abstract
• We examined the psychosocial, demographic, and clinical correlates of familial subtypes of primary unipolar depression. Our findings supported the hypothesis that depression spectrum disease is a variant of neurotic depression, whereas familial pure depressive disease overlaps with endogenous depression. Patients with depressive spectrum disease experienced more life events, had more marital separations and divorces, had poorer social support, more frequently made a nonserious suicide attempt, and had a less characteristic endogenous symptom profile than patients with familial pure depressive disease. Consistent with our previous report on the relationship between dexamethasone suppression test results and familial subtyping, the broadness of the criteria used to diagnose the patients' first-degree relatives affected the strength of the association between the familial subtypes and the dependent variables.
Author Affiliations
From the Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Footnotes
Accepted for publication June 25, 1985.
Reprint requests to Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Rd, Iowa City, IA 52242 (Mr Zimmerman).
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