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Garth Bissette, PhD; Erik Widerlöv, MD, PhD; Helena Walléus, MD; Ingvar Karlsson, MD, PhD; Kurt Eklund, MD; Anders Forsman, MD, PhD; Charles B. Nemeroff, MD, PhD

Arch Gen Psychiatry. 1986;43(12):1148-1151.

Abstract
• The concentration of somatostatinlike immunoreactivity in cerebrospinal fluid (CSF) from normal, healthy volunteers (n =10) and patients with DSM-III diagnoses of major depression (n=17), schizophrenia (n =11), or dementia (n =29) was measured by a sensitive and specific radioimmunoassay. Statistically significant decreases in CSF concentrations of somatostatinlike immunoreactivity were seen in all three patient populations when compared with controls. These findings confirm previous reports of decreased concentrations of somatostatinlike immunoreactivity in the CSF of patients with depression and dementia and extend this observation to patients with schizophrenia as well. These findings are concordant with the view that reductions in somatostatinlike immunoreactivity concentrations are associated with diseases in which cognitive function is disturbed.

Author Affiliations
From the Departments of Psychiatry (Drs Bissette and Nemeroff) and Pharmacology (Dr Nemeroff), and the Center for Aging and Human Development (Dr Nemeroff), Duke University Medical Center, Durham, NC; the Department of Psychiatry and Neurochemistry, University of Lund, Lund, Sweden (Dr Widerlöv); the Psychiatric Research Center, University of Uppsala, Uppsala, Sweden (Dr Walleús); the Department of Psychiatry and Neurochemistry (Dr Karlsson), and Lillhagen Hospital Department of Psychiatry (Dr Forsman), University of Gothenburg, Hisings Backa, Gothenburg, Sweden; and Sater Hospital, Sater, Sweden (Dr Eklund).

Footnotes
Accepted for publication July 29, 1986.

Reprint requests to Department of Psychiatry, Box 3859, Duke University Medical Center, Durham, NC 27710 (Dr Bissette).

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