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Evidence Against a Genetic Relationship

David L. Pauls, PhD; Charles R. Hurst; Susan D. Kruger, PhD; James F. Leckman, MD; Kenneth K. Kidd, PhD; Donald J. Cohen, MD

Arch Gen Psychiatry. 1986;43(12):1177-1179.

Abstract
• Results of a family study of Gilles de la Tourette's syndrome (TS) suggest that TS and attention deficit disorder (ADD) with hyperactivity are genetically separate disorders transmitted independently in families at risk. Although the rate of TS among the relatives of the two proband groups was virtually the same (10.3% vs 11.1%), the rate of ADD among the relatives of probands with TS and ADD with hyperactivity was approximately eight times higher than the rate of ADD among the relatives of the probands with TS only. In those families where the proband had both TS and ADD, the two traits segregated independently. Therefore, there is no evidence to suggest that the two disorders are genetically related.

Author Affiliations
From the Child Study Center (Drs Pauls, Leckman, and Cohen and Mr Hurst) and the Departments of Human Genetics (Drs Pauls, Kruger, and Kidd) and Psychiatry (Drs Leckman, Kidd, and Cohen), Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Jan 18, 1985.

Reprint requests to Child Study Center, Yale University School of Medicine, 333 Cedar St, PO Box 3333, New Haven, CT 06510 (Dr Pauls).

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