 |
|
A Family Study of the Association of Increased Ventricular Size With Schizophrenia
Lynn E. DeLisi, MD;
Lynn R. Goldin, PhD;
Joel R. Hamovit, MSW;
M. Elizabeth Maxwell, MSW;
David Kurtz, MD;
Elliot S. Gershon, MD
Arch Gen Psychiatry. 1986;43(2):148-153.
Abstract
• Families with more than one individual of the same generation with the diagnosis of schizophrenia were recruited for studies. Brain lateral ventricular size was quantified in 26 schizophrenic subjects from 12 unrelated families, their available well siblings (N=10), and 20 nonpsychotic controls. Lateral ventricular size was significantly greater in the schizophrenics than in their well siblings and controls. In addition, an analysis of variance of the data showed a significant familial component to ventricular size. Although histories of head injury and birth complications were also associated with ventricular size, these were not sufficient to explain both the familial aspect of ventricular size and the association of greater ventricular size with schizophrenia within these families.
Author Affiliations
From the Clinical Neurogenetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.
Footnotes
Accepted for publication July 25, 1985.
Reprint requests to Clinical Neurogenetics Branch, Room 3N/220, Bldg 10, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 (Dr DeLisi).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Volumes of Brain Structures in Twins Discordant for Schizophrenia
Baare et al.
Arch Gen Psychiatry 2001;58:33-40.
ABSTRACT
| FULL TEXT
Regional Gray Matter, White Matter, and Cerebrospinal Fluid Distributions in Schizophrenic Patients, Their Siblings, and Controls
Cannon et al.
Arch Gen Psychiatry 1998;55:1084-1091.
ABSTRACT
| FULL TEXT
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:446-453.
ABSTRACT
| FULL TEXT
Developmental Brain Abnormalities in Schizophrenia: Contributions of Genetic and Perinatal Factors-Reply
Cannon et al.
Arch Gen Psychiatry 1995;52:157-159.
ABSTRACT
Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers: I. Contributions of Genetic and Perinatal Factors
Cannon et al.
Arch Gen Psychiatry 1993;50:551-564.
ABSTRACT
Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients
Degreef et al.
Arch Gen Psychiatry 1992;49:531-537.
ABSTRACT
Antecedents of Predominantly Negativeand Predominantly Positive-Symptom Schizophrenia in a High-Risk Population
Cannon et al.
Arch Gen Psychiatry 1990;47:622-632.
ABSTRACT
Genetic and Perinatal Determinants of Structural Brain Deficits in Schizophrenia
Cannon et al.
Arch Gen Psychiatry 1989;46:883-889.
ABSTRACT
Hat Size in Schizophrenia
DeLisi and Goldin
Arch Gen Psychiatry 1987;44:672-673.
ABSTRACT
|
