This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Preliminary Follow-up Study

Henry A. Nasrallah, MD; Stephen C. Olson, MD; Mona McCalley-Whitters, BSN; Suzanne Chapman, BSN; Charles G. Jacoby, MD

Arch Gen Psychiatry. 1986;43(2):157-159.

Abstract
• Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized.

Author Affiliations
From the Veterans Administration Medical Center (Dr Nasrallah and Ms Chapman), and the Departments of Psychiatry (Drs Nasrallah and Olson and Ms McCalley-Whitters) and Radiology (Dr Jacoby), University of Iowa College of Medicine, Iowa City. Drs Nasrallah and Olson are now with the Department of Psychiatry, The Ohio State University, Columbus.

Footnotes
Accepted for publication March 26, 1985.

Reprint requests to the Department of Psychiatry, The Ohio State University, 473 W 12th Ave, Columbus, OH 43210 (Dr Nasrallah).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

What We Know: Findings That Every Theory of Schizophrenia Should Explain
MacDonald and Schulz
Schizophr Bull 2009;35:493-508.
ABSTRACT | FULL TEXT  

The Concept of Progressive Brain Change in Schizophrenia: Implications for Understanding Schizophrenia
DeLisi
Schizophr Bull 2008;34:312-321.
ABSTRACT | FULL TEXT  

What Happens After the First Episode? A Review of Progressive Brain Changes in Chronically Ill Patients With Schizophrenia
Hulshoff Pol and Kahn
Schizophr Bull 2008;34:354-366.
ABSTRACT | FULL TEXT  

Cavum Septum Pellucidum and Its Increased Prevalence in Schizophrenia: A Neuroembryological Classification
Galarza et al.
J. Neuropsychiatry Clin. Neurosi. 2004;16:41-46.
ABSTRACT | FULL TEXT  

Progressive Structural Brain Abnormalities and Their Relationship to Clinical Outcome: A Longitudinal Magnetic Resonance Imaging Study Early in Schizophrenia
Ho et al.
Arch Gen Psychiatry 2003;60:585-594.
ABSTRACT | FULL TEXT  

Brain Volume Changes in First-Episode Schizophrenia: A 1-Year Follow-up Study
Cahn et al.
Arch Gen Psychiatry 2002;59:1002-1010.
ABSTRACT | FULL TEXT  

Volume Changes in Gray Matter in Patients With Schizophrenia
Hulshoff Pol et al.
Am. J. Psychiatry 2002;159:244-250.
ABSTRACT | FULL TEXT  

Progressive Brain Volume Changes and the Clinical Course of Schizophrenia in Men: A Longitudinal Magnetic Resonance Imaging Study
Mathalon et al.
Arch Gen Psychiatry 2001;58:148-157.
ABSTRACT | FULL TEXT  

Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism
Woods
Am. J. Psychiatry 1998;155:1661-1670.
ABSTRACT | FULL TEXT  

Cerebral Gray Matter Volume Deficits in First Episode Psychosis
Zipursky et al.
Arch Gen Psychiatry 1998;55:540-546.
ABSTRACT | FULL TEXT  

Progressive Reduction of Temporal Lobe Structures in Childhood-Onset Schizophrenia
Jacobsen et al.
Am. J. Psychiatry 1998;155:678-685.
ABSTRACT | FULL TEXT  

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia: Relationship of Neuroanatomical Changes to Clinical and Neurobehavioral Measures
Gur et al.
Arch Gen Psychiatry 1998;55:145-152.
ABSTRACT | FULL TEXT  

Sex Differences in Brain Morphology in Schizophrenia
Nopoulos et al.
Am. J. Psychiatry 1997;154:1648-1654.
ABSTRACT | FULL TEXT  

Childhood-Onset Schizophrenia: Progressive Ventricular Change During Adolescence
Rapoport et al.
Arch Gen Psychiatry 1997;54:897-903.
ABSTRACT  

Neurobiology and Neuroplasticity in Schizophrenia: Continuity Across the Life Cycle
Truth is revealed gradually lest it blinds! Emily et al.
Arch Gen Psychiatry 1997;54:913-914.
ABSTRACT  

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia
Zipursky et al.
Arch Gen Psychiatry 1992;49:195-205.
ABSTRACT  

Magnetic Resonance Imaging Abnormalities in Lenticular Nuclei and Cerebral Cortex in Schizophrenia
Jernigan et al.
Arch Gen Psychiatry 1991;48:881-890.
ABSTRACT  

Ventricular Enlargement in Schizophrenia Evaluated With Computed Tomographic Scanning: Effects of Gender, Age, and Stage of Illness
Andreasen et al.
Arch Gen Psychiatry 1990;47:1008-1015.
ABSTRACT  

Ventricle-Brain Ratio, Computed Tomographic Density, and Brain Area in 50 Schizophrenics
Pearlson et al.
Arch Gen Psychiatry 1989;46:690-697.
ABSTRACT