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Martin Harrow, PhD; Linda S. Grossman, PhD; Marshall L. Silverstein, PhD; Herbert Y. Meltzer, MD; Randy L. Kettering, PhD

Arch Gen Psychiatry. 1986;43(8):781-785.

Abstract
• To study the persistence of thought disorder in manic patients, 34 manic patients were compared with 30 schizophrenic and 30 nonpsychotic patients on four indexes of thought pathology at two phases of disorder: during the acute inpatient phase and one year after hospitalization. Patients were also compared with a control sample of 34 normal subjects. The data indicated that (1) during the acute inhospital phase, both manic and schizophrenic patients were severely thought disordered; (2) at follow-up, a subsample of manic patients showed severe thought disorder; (3) despite the severe thought disorder found at follow-up in some manic and schizophrenic patients, both groups showed a significant reduction of thought pathology at follow-up; and (4) there was a trend for a larger reduction of thought disorder in manic than in schizophrenic patients. The difference, however, was not significant when initial levels of severity were controlled.

Author Affiliations
From the Department of Psychiatry, Michael Reese Hospital and Medical Center, Chicago (Dr Harrow); the Departments of Psychiatry (Drs Harrow and Meltzer) and Behavioral Sciences (Dr Harrow), University of Chicago; the Issac Ray Center, Section on Psychiatry and the Law, Department of Psychiatry, Rush-Presbyterian—St Luke's Medical Center, Chicago (Dr Grossman); the Laboratory of Biological Psychiatry, Illinois State Psychiatric Institute, Chicago (Drs Silverstein and Meltzer); Northwestern University, Evanston, Ill (Dr Silverstein); and Gary (Ind) Community Mental Health Center (Dr Kettering).

Footnotes
Accepted for publication Dec 14, 1984.

Read in part at the 134th annual meeting of the American Psychiatric Association, New Orleans, May 14, 1981.

Reprint requests to Department of Psychiatry, Michael Reese Hospital and Medical Center, Lake Shore Drive at 31st Street, Chicago, IL 60616 (Dr Harrow).

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