This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Valid Subtype?

Michael E. Thase, MD; David J. Kupfer, MD; Richard F. Ulrich, MA

Arch Gen Psychiatry. 1986;43(9):886-893.

Abstract
• Electroencephalographic (EEG) sleep patterns were examined in 27 psychotic and 79 nonpsychotic subjects with major depression to evaluate the validity of the psychoticnonpsychotlc subtype dichotomy. Sleep in psychotic depression was characterized by increased wakefulness, decreased rapid eye movement (REM) sleep percentage, and decreased REM activity even after controlling for clinical differences in age, severity, and agitation. Psychotic depressive subjects also were more likely to have extremely short sleep-onset REM latencies. In psychotic depression EEG sleep varied as a function of total illness duration. Patients with recent-onset syndromes had profiles characterized by marked initial insomnia, Increased stage 1 sleep percentage, and long REM latency; patients with illnesses of longer duration had extremely short REM latencies. Demonstration of selected EEG sleep variables discriminating between psychotic and nonpsychotic depression further supports psychotic depression as a distinct subtype of major affective disorder.

Author Affiliations
From the Department of Psychiatry, University of Pittsburgh School of Medicine, and the Western Psychiatric Institute and Clinic, Pittsburgh.

Footnotes
Accepted for publication April 29, 1985.

Read in part at the annual meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, Dec 12, 1983.

Reprint requests to Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213 (Dr Thase).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Current Issues in the Classification of Psychotic Major Depression
Keller et al.
Schizophr Bull 2007;33:877-885.
ABSTRACT | FULL TEXT  

Abnormal Electroencephalographic Sleep Profiles in Major Depression: Association With Response to Cognitive Behavior Therapy
Thase et al.
Arch Gen Psychiatry 1996;53:99-108.
ABSTRACT  

Rapid Eye Movement Sleep Eye Movements in Schizophrenia and Depression
Benson and Zarcone
Arch Gen Psychiatry 1993;50:474-482.
ABSTRACT  

Sleep in Schizophrenic Patients On and Off Haloperidol Therapy: Clinically Stable vs Relapsed Patients
Neylan et al.
Arch Gen Psychiatry 1992;49:643-649.
ABSTRACT  

Sleep and Psychiatric Disorders: A Meta-analysis
Benca et al.
Arch Gen Psychiatry 1992;49:651-668.
ABSTRACT  

Polysomnographic Characteristics of Young Manic Patients: Comparison With Unipolar Depressed Patients and Normal Control Subjects
Hudson et al.
Arch Gen Psychiatry 1992;49:378-383.
ABSTRACT  

Electroencephalographic Sleep Abnormalities in Schizophrenia: Relationship to Positive/Negative Symptoms and Prior Neuroleptic Treatment
Tandon et al.
Arch Gen Psychiatry 1992;49:185-194.
ABSTRACT  

The Validity of Major Depression With Psychotic Features Based on a Community Study
Johnson et al.
Arch Gen Psychiatry 1991;48:1075-1081.
ABSTRACT  

Brain Imaging Abnormalities in Mental Disorders of Late Life
Zubenko et al.
Arch Neurol 1990;47:1107-1111.
ABSTRACT  

Predictors of Drug Response in Depression
Joyce and Paykel
Arch Gen Psychiatry 1989;46:89-99.
ABSTRACT  

Reliable Discrimination of Elderly Depressed and Demented Patients by Electroencephalographic Sleep Data
Reynolds et al.
Arch Gen Psychiatry 1988;45:258-264.
ABSTRACT  

Electroencephalographic Sleep in Mania
Hudson et al.
Arch Gen Psychiatry 1988;45:267-273.
ABSTRACT  

Electroencephalographic Sleep in Young, Never-Medicated Schizophrenics: A Comparison With Delusional and Nondelusional Depressives and With Healthy Controls
Ganguli et al.
Arch Gen Psychiatry 1987;44:36-44.
ABSTRACT