Carbon Dioxide Sensitivity in Panic Anxiety: Ventilatory and Anxiogenic Response to Carbon Dioxide in Healthy Subjects and Patients With Panic Anxiety Before and After Alprazolam Treatment

doi:10.1001/archpsyc.1986.01800090090013

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 43 No. 9, September 1986

Online Only
	•	Online First Table of Contents

ORIGINAL ARTICLES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (164)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Carbon Dioxide Sensitivity in Panic Anxiety

Ventilatory and Anxiogenic Response to Carbon Dioxide in Healthy Subjects and Patients With Panic Anxiety Before and After Alprazolam Treatment

Scott W. Woods, MD; Dennis S. Charney, MD; Jacob Loke, MD; Wayne K. Goodman, MD; D. Eugene Redmond, Jr, MD; George R. Heninger, MD

Arch Gen Psychiatry. 1986;43(9):900-909.

Abstract

• One hypothesis that could account for the anxiogenicresponse to breathing air supplemented with carbon dioxide seenin panic anxiety patients is that panic patients might haveabnormally high central medullary chemoreceptor sensitivity.Chemoreceptor sensitivity was assessed by using a rebreathingtechnique to measure the ventilatory response to CO₂ in 14 medication-freepatients with agoraphobia and panic attacks and 23 healthy subjects.Ventilatory response to CO₂ was similar in patients and controls(mean±SEM, 1.58 ± 0.16 vs 1.58±0.14 L/min/mmHg), suggesting that abnormal chemoreceptor sensitivity doesnot explain the behavioral sensitivity of panic patients toCO₂. Anxiety ratings Increased markedly during rebreathing bothin patients and controls; anxiety increases were significantlygreater in patients than In healthy subjects matched for age,sex, and rebreathing duration. Alprazolam treatment in eightpatients markedly attenuated anxiety increases during rebreathing.Differences in anxiogenic sensitivity to CO₂ between patientsand controls may be due to differences in the regulation ofnoradrenergic or other neuronal systems.

Author Affiliations

From the Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, Department of Psychiatry (Drs Woods, Charney, Goodman, Redmond, and Heninger), and Pulmonary Function Laboratory, Department of Medicine (Dr Loke), Yale University School of Medicine, New Haven, Conn.

Footnotes

Accepted for publication Aug 2, 1985.

Reprint requests to Clinical Neuroscience Research Unit, RibicoffResearch Facilities, Connecticut Mental Health Center, 34 ParkSt, New Haven, CT 06508 (Dr Woods).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Validating the inhalation of 7.5% CO2 in healthy volunteers as a human experimental medicine: a model of generalized anxiety disorder (GAD)
Bailey et al.
J Psychopharmacol 2011;25:1192-1198.
ABSTRACT | FULL TEXT

The effects of single dose anxiolytic medication on the CO2 models of anxiety: differentiation of subjective and objective measures
Papadopoulos et al.
J Psychopharmacol 2010;24:649-656.
ABSTRACT

A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety
Bailey et al.
J Psychopharmacol 2009;23:117-122.
ABSTRACT

A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers
Bailey et al.
J Psychopharmacol 2007;21:42-49.
ABSTRACT

The effects of tianeptine or paroxetine on 35% CO2 provoked panic in panic disorder
Schruers and Griez
J Psychopharmacol 2004;18:553-558.
ABSTRACT

Respiratory Dysregulation in Anxiety, Functional Cardiac, and Pain Disorders: Assessment, Phenomenology, and Treatment
Wilhelm et al.
Behav Modif 2001;25:513-545.
ABSTRACT

Slow Recovery From Voluntary Hyperventilation in Panic Disorder
Wilhelm et al.
Psychosom. Med. 2001;63:638-649.
ABSTRACT | FULL TEXT

Orthostatic increase of respiratory gas exchange in hyperventilation syndrome
Malmberg et al.
Thorax 2000;55:295-301.
ABSTRACT | FULL TEXT

Ventilatory Physiology of Children and Adolescents With Anxiety Disorders
Pine et al.
Arch Gen Psychiatry 1998;55:123-129.
ABSTRACT | FULL TEXT

Haloperidol Addition in Fluvoxamine-Refractory Obsessive-Compulsive Disorder: A Double-blind, Placebo-Controlled Study in Patients With and Without Tics
McDougle et al.
Arch Gen Psychiatry 1994;51:302-308.
ABSTRACT

The cholecystokinin hypothesis of panic and anxiety disorders: a review
Bradwejn et al.
J Psychopharmacol 1992;6:345-351.
ABSTRACT

The Diagnostic Utility of Lactate Sensitivity in Panic Disorder
Cowley and Arana
Arch Gen Psychiatry 1990;47:277-284.
ABSTRACT

Clinical and Medication Outcome After Short-term Alprazolam and Behavorial Group Treatment in Panic Disorder: 2.5-Year Naturalistic Follow-up Study
Nagy et al.
Arch Gen Psychiatry 1989;46:993-999.
ABSTRACT

The Influence of an Illusion of Control on Panic Attacks Induced via Inhalation of 5.5% Carbon Dioxide-Enriched Air
Sanderson et al.
Arch Gen Psychiatry 1989;46:157-162.
ABSTRACT

Electroencephalographic Sleep in Panic Disorder: A Focus on Sleep-Related Panic Attacks
Mellman and Uhde
Arch Gen Psychiatry 1989;46:178-184.
ABSTRACT

Ventilatory Physiology of Patients With Panic Disorder
Gorman et al.
Arch Gen Psychiatry 1988;45:31-39.
ABSTRACT

Carbon Dioxide--Induced Anxiety: Behavioral, Physiologic, and Biochemical Effects of Carbon Dioxide in Patients With Panic Disorders and Healthy Subjects
Woods et al.
Arch Gen Psychiatry 1988;45:43-52.
ABSTRACT

Situational Panic Attacks: Behavioral, Physiologic, and Biochemical Characterization
Woods et al.
Arch Gen Psychiatry 1987;44:365-375.
ABSTRACT

| | |