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Jerome A. Yesavage, MD; Elizabeth Decker Tanke, PhD; Javaid I. Sheikh, MD

Arch Gen Psychiatry. 1987;44(10):913-915.

Abstract
• The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.

Author Affiliations
From the Department of Psychiatry and Behavioral Sciences, Stanford (Calif) University School of Medicine; and Palo Alto (Calif) Veterans Administration Medical Center.

Footnotes
Accepted for publication March 31, 1987.

Reprint requests to Department of Psychiatry and Behavioral Sciences (TD-114), Stanford University School of Medicine, Stanford, CA 94305 (Dr Yesavage).

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