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Comparison of Patients and Healthy Controls

Joseph Zohar, MD; Edward A. Mueller, MD; Thomas R. Insel, MD; Rachel C. Zohar-Kadouch, MD; Dennis L. Murphy, MD

Arch Gen Psychiatry. 1987;44(11):946-951.

Abstract
• To examine the "serotonin hypothesis" of obsessivecompulsive disorder (OCD), we studied the behavioral and neuroendocrine effects of metachlorophenylpiperazine (mCPP), a serotonergic agonist, in patients with OCD and healthy controls. Twelve patients and 20 controls were given a single dose of 0.5 mg/kg of mCPP, administered orally under double-blind, placebo-controlled, random-assignment conditions. Following mCPP, but not following placebo, patients with OCD experienced a transient but marked exacerbation of obsessive-compulsive symptoms. Moreover, compared with healthy controls, patients exhibited greater other behavioral (but not endocrinologic or thermal) changes after mCPP. These findings are consistent with a special role for the neurotransmitter serotonin in OCD psychopathology.

Author Affiliations
From the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication March 5, 1987.

Reprint requests to Laboratory of Clinical Science, National Institute of Mental Health, Clinical Center, 10/3D-41, Bethesda, MD 20892 (Dr Zohar).

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