This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Replication

Frederic M. Quitkin, MD; Judith D. Rabkin, PhD; Jefferey M. Markowitz, MPH; Jonathan W. Stewart, MD; Patrick J. McGrath, MD; Wilma Harrison, MD

Arch Gen Psychiatry. 1987;44(3):259-264.

Abstract
• In any antidepressant study, placebo response in patients assigned active drug is a troubling source of variance. There have been few attempts to identify the patients whose conditions improve as a result of true drug effect, in contrast with improvement that is a result of nonspecific effects. In a previous report we demonstrated that true drug effect seemed to be characterized by a two-week delay in onset and persistence. We described a method of pattern analysis to identify such patients. In this report, we describe the use of pattern analysis to replicate our initial findings. Data from a new sample of 150 nonmelancholic patients support the hypothesis that true drug effect is characterized by a two-week delay in onset and persistence of improvement, once achieved. There was little evidence of the onset of antidepressant effect before two weeks. The theoretical and clinical implications of this work are discussed.

Author Affiliations
From the New York State Pyschiatric Institute, New York, and the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Accepted for publication Nov 6, 1985.

Reprint requests to Office of Mental Health, New York State Psychiatric Institute, 722 W 168th St, New York, NY 10032 (Dr Quitkin).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pharmacogenetics Studies in STAR*D: Strengths, Limitations, and Results
Laje et al.
Psychiatr. Serv. 2009;60:1446-1457.
ABSTRACT | FULL TEXT  

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines
Anderson et al.
J Psychopharmacol 2008;22:343-396.
ABSTRACT  

Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis.
Taylor et al.
Arch Gen Psychiatry 2006;63:1217-1223.
ABSTRACT | FULL TEXT  

Two-week delay in onset of action of antidepressants: new evidence
MITCHELL
Br. J. Psychiatry 2006;188:105-106.
ABSTRACT | FULL TEXT  

Serotonin Clearance In Vivo Is Altered to a Greater Extent by Antidepressant-Induced Downregulation of the Serotonin Transporter than by Acute Blockade of this Transporter
Benmansour et al.
J. Neurosci. 2002;22:6766-6772.
ABSTRACT | FULL TEXT  

Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh et al.
JAMA 2002;287:1840-1847.
ABSTRACT | FULL TEXT  

National Depressive and Manic-Depressive Association Consensus Statement on the Use of Placebo in Clinical Trials of Mood Disorders
Charney et al.
Arch Gen Psychiatry 2002;59:262-270.
ABSTRACT | FULL TEXT  

Timing of Onset of Antidepressant Response With Fluoxetine Treatment
Nierenberg et al.
Am. J. Psychiatry 2000;157:1423-1428.
ABSTRACT | FULL TEXT  

Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder: A Randomized Controlled Trial
Barlow et al.
JAMA 2000;283:2529-2536.
ABSTRACT | FULL TEXT  

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines
Anderson et al.
J Psychopharmacol 2000;14:3-20.
ABSTRACT  

Use of Pattern Analysis to Predict Differential Relapse of Remitted Patients With Major Depression During 1 Year of Treatment With Fluoxetine or Placebo
Stewart et al.
Arch Gen Psychiatry 1998;55:334-343.
ABSTRACT | FULL TEXT  

Chronological Milestones to Guide Drug Change: When Should Clinicians Switch Antidepressants?
Quitkin et al.
Arch Gen Psychiatry 1996;53:785-792.
ABSTRACT  

Predictors of Drug Response in Depression
Joyce and Paykel
Arch Gen Psychiatry 1989;46:89-99.
ABSTRACT